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通过定义稳健功能架构的复杂关联模式层次来研究哺乳动物脑动力学的方案。

Protocol to study brain dynamics of mammals through the hierarchy of complex correlation patterns defining a robust functional architecture.

作者信息

Varga Levente, Péntek Balázs, Molnár Botond, Perez-Cervera Laura, Selim Mohamed Kotb, Díaz-Parra Antonio, Moratal David, Sommer Wolfgang H, Canals Santiago, Mureșan Raul C, Moca Vasile V, Ercsey-Ravasz Maria

机构信息

Faculty of Mathematics and Computer Science, Babeș-Bolyai University, Cluj-Napoca, Romania; Faculty of Physics, Babeș-Bolyai University, Cluj-Napoca, Romania; Transylvanian Institute of Neuroscience, Cluj-Napoca, Romania.

Faculty of Physics, Babeș-Bolyai University, Cluj-Napoca, Romania.

出版信息

STAR Protoc. 2025 Mar 20;6(2):103693. doi: 10.1016/j.xpro.2025.103693.

Abstract

Analyzing functional networks (FNs) of brain activity of mammals can be challenging because of their fast dynamics and non-stationary properties. Here, we present a computational protocol for extracting FNs using scaled cross-correlation (SCA) and analyzing them independently for each epoch. We outline procedures for calculating edge weight and node distance distributions, with statistical comparisons using the Cliff's delta metric. We also detail procedures for visualizing results by plotting distributions. This protocol has potential in identifying disease biomarkers. For complete details on the use and execution of this protocol, please refer to Varga et al..

摘要

由于哺乳动物大脑活动的功能网络(FNs)具有快速动态性和非平稳特性,对其进行分析可能具有挑战性。在此,我们提出一种计算协议,用于使用缩放互相关(SCA)提取FNs,并针对每个时期独立分析它们。我们概述了计算边权重和节点距离分布的程序,并使用Cliff's delta度量进行统计比较。我们还详细介绍了通过绘制分布来可视化结果的程序。该协议在识别疾病生物标志物方面具有潜力。有关此协议使用和执行的完整详细信息,请参考瓦尔加等人的研究。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/86d6/11976250/d5c73e92a2ea/fx1.jpg

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