Zhang Huhu, Sun Fulin, Cao Hongyu, Yang Lina, Yang Fanghao, Chen Ruolan, Jiang Shuyao, Wang Ruixuan, Yu Xin, Li Bing, Chu Xianming
Department of Cardiology, the Affiliated Hospital of Qingdao University, No. 59 Haier Road, Qingdao 266100, Shandong, China; Department of Genetics and Cell Biology, School of Basic Medicine, Qingdao University, Qingdao 266071, China.
Department of Genetics and Cell Biology, School of Basic Medicine, Qingdao University, Qingdao 266071, China; Health Science Center, Qingdao University, Qingdao 266071, China.
Int J Biol Macromol. 2025 May;308(Pt 2):142277. doi: 10.1016/j.ijbiomac.2025.142277. Epub 2025 Mar 21.
The Ubiquitin A (UBA) protein family contains seven members that protect themselves or their interacting proteins from proteasome degradation. The UBA protein family regulates cell proliferation, cell cycle, invasion, migration, apoptosis, autophagy, tissue differentiation, and immune response. With the deepening of research, the UBA protein family has been found to be abnormally expressed in a variety of tumor diseases, and the clarification of its relationship with tumor diseases can be used as a molecular therapeutic target and have an important role in the prognosis of tumors. In this paper, we review the structure, biological process, target therapy, and biomarkers of the UBA protein family to provide new ideas for the diagnosis and treatment of tumors.
泛素A（UBA）蛋白家族包含七个成员，这些成员可保护自身或其相互作用的蛋白质免受蛋白酶体降解。UBA蛋白家族调节细胞增殖、细胞周期、侵袭、迁移、凋亡、自噬、组织分化和免疫反应。随着研究的深入，已发现UBA蛋白家族在多种肿瘤疾病中异常表达，阐明其与肿瘤疾病的关系可作为分子治疗靶点，并在肿瘤预后中发挥重要作用。在本文中，我们综述了UBA蛋白家族的结构、生物学过程、靶向治疗和生物标志物，为肿瘤的诊断和治疗提供新思路。
