Morovat Saman, Morovat Pejman, Kalantary-Charvadeh Ashkan, Mojbafan Marzieh, Teimourian Shahram
Department of Medical Genetics, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Razi Vaccine & Serum Research Institute, P.O. Box 31975-148, Karaj, Iran.
Med Oncol. 2025 Jul 12;42(8):325. doi: 10.1007/s12032-025-02889-w.
LINC01410 is classified as a long non-coding RNA (lncRNA) that plays a pivotal role in cancer biology. Non-coding RNAs, including lncRNAs, have been recognized for their significant regulatory functions in various cellular processes, making them crucial for understanding the mechanisms underlying cancer development and progression. This review aims to synthesize the current knowledge of LINC01410's contributions to cancer development, and progression across different tumor types, highlighting its potential roles as a biomarker and therapeutic target. A comprehensive literature review was performed, encompassing experimental, clinical, and bioinformatics studies that examined LINC01410's expression profiles and functional roles in various cancers. Studies were selected based on their relevance to LINC01410's involvement in oncogenic processes and their methodological rigor. LINC01410 exhibits differential expression in several cancers, often correlates with tumor aggressiveness and patient prognosis. Mechanistically, LINC01410 acts as a competing endogenous RNA, regulating gene expression by sequestering microRNAs, which in turn modulates the expression of target mRNAs. This lncRNA has been implicated in promoting cancer cell proliferation, invasion, lymphangiogenesis, and chemoradiotherapy resistance underscoring its multifaceted roles in tumor biology. The exploration of LINC01410 has important implications in cancer diagnosis and therapy, positioning it as a potential biomarker for disease progression and a therapeutic target for intervention strategies.
LINC01410被归类为一种长链非编码RNA（lncRNA），在癌症生物学中发挥着关键作用。包括lncRNA在内的非编码RNA因其在各种细胞过程中的重要调节功能而受到认可，这使其对于理解癌症发生和发展的机制至关重要。本综述旨在综合目前关于LINC01410对癌症发生和不同肿瘤类型进展贡献的知识，突出其作为生物标志物和治疗靶点的潜在作用。我们进行了全面的文献综述，涵盖了研究LINC01410在各种癌症中的表达谱和功能作用的实验、临床和生物信息学研究。根据研究与LINC01410参与致癌过程的相关性及其方法的严谨性来选择研究。LINC01410在几种癌症中表现出差异表达，通常与肿瘤侵袭性和患者预后相关。从机制上讲，LINC01410作为一种竞争性内源性RNA，通过隔离微小RNA来调节基因表达，进而调节靶mRNA的表达。这种lncRNA与促进癌细胞增殖、侵袭淋巴管生成和放化疗耐药性有关，突显了其在肿瘤生物学中的多方面作用。对LINC01410的探索在癌症诊断和治疗中具有重要意义，使其成为疾病进展的潜在生物标志物和干预策略的治疗靶点。
