Li Shiyu, Jiao Fangyang, Li Xiuyuan, Xu Zhiheng, Hu Tianyu, Liang Xiaoniu, Wu Jianjun, Wang Jian, Zuo Chuantao, Tang Yilin
Department of Neurology and National Research Center for Aging and Medicine & National Center for Neurological Disorders, State Key Laboratory of Medical Neurobiology, Huashan Hospital, Fudan University, Shanghai, China.
Department of Nuclear Medicine &PET Center, Huashan Hospital, Fudan University, Shanghai, China.
NPJ Parkinsons Dis. 2025 Mar 22;11(1):54. doi: 10.1038/s41531-025-00898-0.
The recently proposed body-first and brain-first subtypes are classified based on the initial localization of α-synuclein inclusions. This study investigated plasma biomarkers and cerebral glucose metabolism characteristics in putative brain-first and body-first subtypes in PD subjects. PD patients without possible RBD (PD) (n = 58) and with possible RBD symptoms discovered before motor symptoms (PD) (n = 43) were recruited. Single-molecule array (SimoA) was used for measuring plasma biomarkers, including glial fibrillary acidic protein (GFAP), neurofilament light chain (NfL), Tau and phosphorylated-tau 181 (pTau-181). All participants underwent F-fluorodeoxyglucose (FDG) PET scans. Compared to PD patients, PD patients exhibited significantly increased plasma GFAP levels and reduced F-FDG uptake in cortical regions. Notably, plasma GFAP and NfL levels correlated with cerebral glucose metabolism in PD patients. Our study identified the association between plasma GFAP and NfL levels and cerebral glucose metabolism in PD patients. Further large-scale longitudinal studies are required.
最近提出的身体优先和大脑优先亚型是根据α-突触核蛋白包涵体的初始定位进行分类的。本研究调查了帕金森病（PD）患者中假定的大脑优先和身体优先亚型的血浆生物标志物和脑葡萄糖代谢特征。招募了无可能快速眼动睡眠行为障碍（RBD）的PD患者（n = 58）和在运动症状出现前发现有RBD症状的PD患者（n = 43）。使用单分子阵列（SimoA）测量血浆生物标志物，包括胶质纤维酸性蛋白（GFAP）、神经丝轻链（NfL）、Tau和磷酸化Tau 181（pTau-181）。所有参与者均接受了氟代脱氧葡萄糖（FDG）PET扫描。与PD患者相比，PD患者血浆GFAP水平显著升高，皮质区域F-FDG摄取减少。值得注意的是，PD患者血浆GFAP和NfL水平与脑葡萄糖代谢相关。我们的研究确定了PD患者血浆GFAP和NfL水平与脑葡萄糖代谢之间的关联。需要进一步的大规模纵向研究。
