Xu Zhiheng, Hu Tianyu, Xu Chenqin, Liang Xiaoniu, Li Shiyu, Sun Yimin, Liu Fengtao, Wang Jian, Tang Yilin
Department of Neurology and National Research Center for Aging and Medicine and National Center for Neurological Disorders, State Key Laboratory of Medical Neurobiology, Huashan Hospital, Fudan University, Shanghai, China.
NPJ Parkinsons Dis. 2024 Jun 4;10(1):111. doi: 10.1038/s41531-024-00730-1.
A new Parkinson's disease (PD) subtyping model has been recently proposed based on the initial location of α-synuclein inclusions, which divides PD patients into the brain-first subtype and the body-first subtype. Premotor RBD has proven to be a predictive marker of the body-first subtype. We found compared to PD patients without possible RBD (PD, representing the brain-first subtype), PD patients with possible premotor RBD (PD, representing the body-first subtype) had lower Movement Disorders Society Unified Parkinson's Disease Rating Scale part III (MDS UPDRS-III) score (p = 0.022) at baseline but presented a faster progression rate (p = 0.009) in MDS UPDRS-III score longitudinally. The above finding indicates the body-first subtype exhibited a faster disease progression in motor impairments compared to the brain-first subtype and further validates the proposed subtyping model.
最近基于α-突触核蛋白包涵体的初始位置提出了一种新的帕金森病（PD）亚型模型，该模型将PD患者分为脑首发亚型和身体首发亚型。运动前快速眼动行为障碍（RBD）已被证明是身体首发亚型的预测标志物。我们发现，与无可能RBD的PD患者（PD，代表脑首发亚型）相比，有运动前可能RBD的PD患者（PD，代表身体首发亚型）在基线时的运动障碍协会统一帕金森病评定量表第三部分（MDS UPDRS-III）评分较低（p = 0.022），但在纵向MDS UPDRS-III评分中呈现出更快的进展速度（p = 0.009）。上述发现表明，与脑首发亚型相比，身体首发亚型在运动障碍方面表现出更快的疾病进展，并进一步验证了所提出的亚型模型。
