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出生后第一周内，暴露于孕期糖尿病环境下的婴儿脂肪因子浓度的变化。

Alterations in infant adipokine concentrations in the first postnatal week with exposure to diabetes in pregnancy.

作者信息

Borden Caroline G, Shabanova Veronika, Taylor Sarah N, Buck Catherine O

机构信息

Department of Pediatrics, Yale School of Medicine, New Haven, CT, USA.

出版信息

J Perinatol. 2025 May;45(5):622-627. doi: 10.1038/s41372-025-02269-2. Epub 2025 Mar 22.

DOI:10.1038/s41372-025-02269-2
PMID:40121331
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12278066/
Abstract

OBJECTIVE

Characterize changes in neonatal energy metabolism hormones in first postnatal week.

STUDY DESIGN

Concentrations of leptin, adiponectin, insulin, resistin, and ghrelin were measured in cord and infant blood collected in the first postnatal week in a prospective cohort of term and preterm infants. Change over time in each hormone was modeled using linear mixed effects regression.

RESULT

Among 106 infants, 65 (61%) were preterm and 44 (42%) were exposed to diabetes (DM) in pregnancy. DM group had higher leptin [between group difference β 2.5 (95%CI: 1.72-3.70)] and resistin [β 1.5 (95%CI:1.14, 1.92)] and lower ghrelin [β 0.49] [95%CI: (0.32-0.76)] versus non-DM group. Preterm infants had lower adiponectin [β 0.80 (95%CI: 0.67-0.96)] versus term group. Insulin varied by DM and prematurity (interaction-term p value < 0.05).

CONCLUSION

In this cohort, hormone concentrations varied by DM and prematurity. Early alterations in energy metabolism hormones may reflect changes in developmental programming which persist in the early postnatal period.

摘要

目的

描述出生后第一周新生儿能量代谢激素的变化。

研究设计

在一个足月和早产婴儿的前瞻性队列中，测量出生后第一周采集的脐带血和婴儿血液中瘦素、脂联素、胰岛素、抵抗素和胃饥饿素的浓度。使用线性混合效应回归对每种激素随时间的变化进行建模。

结果

在106名婴儿中，65名（61%）为早产儿，44名（42%）的母亲在孕期患有糖尿病（DM）。与非糖尿病组相比，糖尿病组的瘦素[组间差异β 2.5（95%CI：1.72 - 3.70）]和抵抗素[β 1.5（95%CI：1.14，1.92）]水平较高，而胃饥饿素[β 0.49][95%CI：（0.32 - 0.76）]水平较低。与足月儿组相比，早产儿的脂联素水平较低[β 0.80（95%CI：0.67 - 0.96）]。胰岛素水平因糖尿病和早产情况而异（交互项p值<0.05）。

结论

在这个队列中，激素浓度因糖尿病和早产情况而异。能量代谢激素的早期改变可能反映了发育编程的变化，这种变化在出生后早期持续存在。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1da5/12278066/bf9a656908f9/nihms-2087775-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1da5/12278066/d3fdabb6349f/nihms-2087775-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1da5/12278066/bf9a656908f9/nihms-2087775-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1da5/12278066/d3fdabb6349f/nihms-2087775-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1da5/12278066/bf9a656908f9/nihms-2087775-f0002.jpg

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Diabetes in Pregnancy, Neonatal Morbidities, and Early Growth in Moderate or Late Preterm Infants.妊娠期糖尿病与中晚早产儿新生儿期并发症及早期生长关系的研究
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