脐血脂肪因子的决定因素及其与新生儿腹部脂肪组织分布的关系。
Determinants of cord blood adipokines and association with neonatal abdominal adipose tissue distribution.
机构信息
Singapore Institute for Clinical Sciences (SICS), Agency for Science, Technology and Research (A*STAR) Singapore, Singapore, Singapore.
Human Potential Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
出版信息
Int J Obes (Lond). 2022 Mar;46(3):637-645. doi: 10.1038/s41366-021-00975-3. Epub 2021 Dec 4.
BACKGROUND
Cord blood leptin and adiponectin are adipokines known to be associated with birth weight and overall infant adiposity. However, few studies have investigated their associations with abdominal adiposity in neonates. We examined maternal factors associated with cord blood leptin and adiponectin, and the association of these adipokines with neonatal adiposity and abdominal fat distribution measured by magnetic resonance imaging (MRI) in an Asian mother-offspring cohort.
METHODS
Growing Up in Singapore Towards healthy Outcomes (GUSTO), is a prospective mother-offspring birth cohort study in Singapore. Cord blood plasma leptin and adiponectin concentrations were measured using Luminex and Enzyme-Linked Immunosorbent Assay respectively in 816 infants. A total of 271 neonates underwent MRI within the first 2-weeks after delivery. Abdominal superficial (sSAT), deep subcutaneous (dSAT), and intra-abdominal (IAT) adipose tissue compartment volumes were quantified from MRI images. Multivariable regression analyses were performed.
RESULTS
Indian or Malay ethnicity, female sex, and gestational age were positively associated with cord blood leptin and adiponectin concentrations. Maternal gestational diabetes (GDM) positively associated with cord blood leptin concentrations but inversely associated with cord blood adiponectin concentrations. Maternal pre-pregnancy body mass index (BMI) showed a positive relationship with cord blood leptin but not with adiponectin concentrations. Each SD increase in cord blood leptin was associated with higher neonatal sSAT, dSAT and IAT; differences in SD (95% CI): 0.258 (0.142, 0.374), 0.386 (0.254, 0.517) and 0.250 (0.118, 0.383), respectively. Similarly, each SD increase in cord blood adiponectin was associated with higher neonatal sSAT and dSAT; differences in SD (95% CI): 0.185 (0.096, 0.274) and 0.173 (0.067, 0.278), respectively. The association between cord blood adiponectin and neonatal adiposity was observed in neonates of obese mothers only.
CONCLUSIONS
Cord blood leptin and adiponectin concentrations were associated with ethnicity, maternal BMI and GDM, sex and gestational age. Both adipokines showed positive association with neonatal abdominal adiposity.
背景
脐带血中的瘦素和脂联素是与出生体重和婴儿整体肥胖有关的脂肪因子。然而，很少有研究调查它们与新生儿腹部肥胖的关系。我们研究了与脐带血瘦素和脂联素相关的母体因素，并在新加坡的一个亚洲母婴队列中，通过磁共振成像（MRI）研究了这些脂肪因子与新生儿肥胖和腹部脂肪分布的关系。
方法
新加坡母婴队列研究 Growing Up in Singapore Towards healthy Outcomes（GUSTO），对 816 名婴儿使用 Luminex 和酶联免疫吸附试验分别测量脐带血血浆瘦素和脂联素浓度。共有 271 名新生儿在分娩后两周内进行了 MRI 检查。从 MRI 图像中定量计算腹部浅层（sSAT）、深皮下（dSAT）和腹内（IAT）脂肪组织体积。进行多变量回归分析。
结果
印度裔或马来裔、女性和胎龄与脐带血瘦素和脂联素浓度呈正相关。母亲患有妊娠糖尿病（GDM）与脐带血瘦素浓度呈正相关，但与脐带血脂联素浓度呈负相关。母亲孕前体重指数（BMI）与脐带血瘦素呈正相关，但与脂联素浓度无关。脐带血瘦素每增加一个标准差（SD），新生儿 sSAT、dSAT 和 IAT 就会增加；SD 的差异（95%CI）：0.258（0.142，0.374）、0.386（0.254，0.517）和 0.250（0.118，0.383）。同样，脐带血脂联素每增加一个 SD，新生儿 sSAT 和 dSAT 就会增加；SD 的差异（95%CI）：0.185（0.096，0.274）和 0.173（0.067，0.278）。只有肥胖母亲的新生儿中，脐带血脂联素与新生儿肥胖有关。
结论
脐带血瘦素和脂联素浓度与种族、母亲 BMI 和 GDM、性别和胎龄有关。两种脂肪因子均与新生儿腹部肥胖呈正相关。
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