Bi Lingbo, Kan Haili, Wang Jing, Ding Yunbu, Huang Yuanbo, Wang Chaofan, Du Yimei, Lu Changpei, Zhao Min, Sun Weiling, Su Tong, Fan Weixin
Department of Dermatology, Jiangsu Province Hospital and the First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Department of Dermatology, China-Japan Friendship Hospital, Beijing, China.
J Dermatolog Treat. 2025 Dec;36(1):2480739. doi: 10.1080/09546634.2025.2480739. Epub 2025 Mar 23.
Minoxidil is a routinely used drug in treating multiple hair disorders. This study aimed to investigate the facticity of the temporal increase in the hair shedding amount after topical use of minoxidil.
We selected 49 patients who used 2% or 5% minoxidil topically to treat androgenetic alopecia for 24 weeks. The amount of hair shedding was recorded every four weeks before and after the treatment. The BASP classification and trichoscopy test results were also recorded before and after the treatment. The relative amount of hair shedding (RAHS) was defined as the recorded number of hair shedding after normalization. The correlation between the maximum RAHS (MRAHS) and the sulfotransferase activity as well as the therapeutic effect was calculated.
A temporary increase in the amount of hair shedding was detected in the first 12 weeks. This increase has a longer duration in patients treated with 2% minoxidil compared to 5%. Its severity was correlated with the improvement of trichoscopy tests only in patients with 5% minoxidil but not in 2%. However, both patients in the 2% and 5% minoxidil groups had a significant association between the MRAHS and the improvement in BASP classification.
The amount of hair shedding increases temporarily after the topical minoxidil use, the level of which is a potential treatment efficacy.
米诺地尔是治疗多种毛发疾病的常用药物。本研究旨在调查局部使用米诺地尔后脱发量随时间增加这一现象的真实性。
我们选取了49例局部使用2%或5%米诺地尔治疗雄激素性脱发24周的患者。在治疗前后每四周记录脱发量。治疗前后还记录了BASP分类和毛发镜检查结果。相对脱发量（RAHS）定义为标准化后记录的脱发数量。计算最大RAHS（MRAHS）与磺基转移酶活性以及治疗效果之间的相关性。
在最初的12周内检测到脱发量暂时增加。与5%米诺地尔治疗的患者相比，2%米诺地尔治疗的患者这种增加持续时间更长。仅在使用5%米诺地尔的患者中，其严重程度与毛发镜检查结果的改善相关，而在使用2%米诺地尔的患者中则不然。然而，2%和5%米诺地尔组的患者MRAHS与BASP分类的改善之间均存在显著关联。
局部使用米诺地尔后脱发量会暂时增加，其程度是潜在的治疗效果指标。
