O'Grady J G, Harding B, Stevens F M, Egan E L, McCarthy C F
Scand J Haematol. 1985 May;34(5):425-8. doi: 10.1111/j.1600-0609.1985.tb00772.x.
Platelet count and volume were measured in 84 splenectomised subjects, 142 patients with coeliac disease and 77 healthy subjects. An inverse, non-linear correlation between platelet count and volume was found in healthy subjects and coeliac patients, but was not present in splenectomised subjects who had higher platelet counts (P = 0.0001) and mean platelet volumes (P = 0.0001) than healthy subjects. Platelet counts correlated with splenic function in patients with coeliac disease and were higher in patients with severe hyposplenism than in normosplenic coeliacs (P = 0.0001). Splenic function did not influence the mean platelet volume (MPV) in coeliac disease but normosplenic coeliacs had higher MPV than normal subjects (P = 0.05). Serum iron and red cell folate were not correlated to MPV in coeliac disease. We conclude that splenic function effects platelet count and volume in non-coeliac subjects and platelet count in coeliac disease. However, other unidentified factor(s) influence the MPV in coeliac disease.
对84名脾切除患者、142名乳糜泻患者和77名健康受试者进行了血小板计数和体积测量。在健康受试者和乳糜泻患者中发现血小板计数与体积呈负向非线性相关，但在脾切除患者中不存在这种相关性，脾切除患者的血小板计数（P = 0.0001）和平均血小板体积（P = 0.0001）高于健康受试者。乳糜泻患者的血小板计数与脾功能相关，重度脾功能减退患者的血小板计数高于脾功能正常的乳糜泻患者（P = 0.0001）。脾功能不影响乳糜泻患者的平均血小板体积（MPV），但脾功能正常的乳糜泻患者的MPV高于正常受试者（P = 0.05）。乳糜泻患者的血清铁和红细胞叶酸与MPV不相关。我们得出结论，脾功能影响非乳糜泻受试者的血小板计数和体积以及乳糜泻患者的血小板计数。然而，其他未明确的因素影响乳糜泻患者的MPV。
