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[老年患者的严重症状性瓣膜缺陷。自然预后和手术结果]

[Severe symptomatic valve defects in elderly patients. Spontaneous prognosis and surgical results].

作者信息

Turina J, Hess O M, Turina M, Krayenbühl H P

出版信息

Schweiz Med Wochenschr. 1985 May 18;115(20):698-702.

PMID:4012247
Abstract

Between 1970 and 1982 125 patients aged, 65 to 79 years with severe symptomatic valvular heart disease. Aortic valve disease (72 with aortic stenosis) was encountered in 76 cases, mitral valve disease (22 with mitral regurgitation) in 32 and combined aortic and mitral lesions in 17. Additional severe coronary artery disease (narrowing greater than 70%) was present in 25% of the patients. 80% of the patients were in NYHA class III and IV, and 42% had experienced an episode of congestive heart failure. 28 patients did not undergo surgery; 10 died before surgery and 18 were not accepted or refused the operation. After 2 years only 1 of 18 patients with aortic stenosis was alive; in mitral valve disease 5 of 6 patients were alive. Among the 97 surgical patients, aortic valve replacement was performed in 58 cases, mitral valve surgery in 26 and combined aortic and mitral valve surgery in 13. Additional aorto-coronary bypass grafting was performed in 23 patients. Early mortality was 5% and 5-year survival rate 69%. NYHA class declined from 2.9 preoperatively to 1.6 postoperatively. In the elderly patient with severe symptomatic valvular heart disease surgery can be performed with acceptable operative risk and good late results. Surgical treatment is particularly indicated in aortic stenosis, due to the poor spontaneous prognosis. Coronary artery disease is frequent in this age group but is not a contraindication for surgery, in view of the good postoperative results of additional aorto-coronary bypass grafting.

摘要

1970年至1982年间,125例年龄在65至79岁之间的患者患有严重的症状性瓣膜性心脏病。其中76例为主动脉瓣疾病(72例为主动脉瓣狭窄),32例为二尖瓣疾病(22例为二尖瓣反流),17例为主动脉瓣和二尖瓣联合病变联合联合病变。25%的患者还患有严重的冠状动脉疾病(狭窄程度大于70%)。80%的患者属于纽约心脏协会(NYHA)心功能III级和IV级,42%的患者曾发生过充血性心力衰竭。28例患者未接受手术;10例在手术前死亡,18例未被接受或拒绝手术。2年后,18例主动脉瓣狭窄患者中只有1例存活;二尖瓣疾病患者中6例有5例存活。在97例接受手术的患者中,58例行主动脉瓣置换术,26例行二尖瓣手术,13例行主动脉瓣和二尖瓣联合手术。23例患者还进行了主动脉冠状动脉搭桥术。早期死亡率为5%,5年生存率为69%。NYHA心功能分级从术前的2.9降至术后的1.6。对于患有严重症状性瓣膜性心脏病的老年患者,可以进行手术,手术风险可接受,远期效果良好。鉴于自发预后较差,手术治疗尤其适用于主动脉瓣狭窄。考虑到主动脉冠状动脉搭桥术术后效果良好,该年龄组冠状动脉疾病常见,但并非手术禁忌证。

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