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重塑疫苗:疾病预防中的肽革命。

Vaccines reimagined: The peptide revolution in disease prevention.

作者信息

Chavda Vivek P

机构信息

Department of Pharmaceutics and Pharmaceutical Technology, L. M. College of Pharmacy, Ahmedabad, Gujarat, India.

出版信息

Prog Mol Biol Transl Sci. 2025;212:329-354. doi: 10.1016/bs.pmbts.2024.11.002. Epub 2025 Jan 30.

Abstract

Peptide-based vaccines have emerged as a promising avenue in the realm of immunization strategies. This chapter provides an overview of the key aspects and advancements in peptide-based vaccine development. Peptides, as fragments of larger proteins, hold the potential to induce targeted immune responses while minimizing off-target effects. We discuss the principles of peptide selection, epitope identification, and delivery platforms, underscoring the importance of rational design to optimize immunogenicity. The integration of computational tools and advanced analytical methods has enabled the refinement of peptide vaccine candidates. Studies on infectious diseases, cancers, and new pathogens showcase the versatility and efficacy of peptide vaccines. As the field progresses, collaborative efforts between researchers, industry, and healthcare systems are essential to bridge the gap from laboratory research to clinical application. The future holds promise for peptide-based vaccines to contribute significantly to disease prevention and therapeutic intervention.

摘要

基于肽的疫苗已成为免疫策略领域中一条充满希望的途径。本章概述了基于肽的疫苗开发的关键方面和进展。肽作为较大蛋白质的片段,有潜力诱导靶向免疫反应,同时将脱靶效应降至最低。我们讨论了肽的选择、表位鉴定和递送平台的原则,强调了合理设计以优化免疫原性的重要性。计算工具和先进分析方法的整合使得候选肽疫苗得以优化。对传染病、癌症和新病原体的研究展示了肽疫苗的多功能性和有效性。随着该领域的发展,研究人员、产业界和医疗保健系统之间的合作努力对于弥合从实验室研究到临床应用的差距至关重要。基于肽的疫苗未来有望为疾病预防和治疗干预做出重大贡献。

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