长期给予镉后大鼠胎盘的光学显微镜观察结果

Light microscopic aspects of the rat placenta after chronic cadmium administration.

作者信息

Hazelhoff Roelfzema W, Roelofsen A M, Copius Peereboom-Stegeman J H

出版信息

Sci Total Environ. 1985 Mar 15;42(1-2):181-4. doi: 10.1016/0048-9697(85)90017-8.

Abstract

Female Wistar rats were injected daily with different doses of CdCl2 during the first 19 days of pregnancy. The placentas of highly exposed animals showed reduced weights as well as some light microscopic changes with respect to the amount of collagen in the basal membranes around fetal blood vessels and to the relative volume densities of the fetal blood vessels. These results are in accordance with changes, found in the placentas of smoking mothers, probably due to cadmium in cigarette smoke.

摘要

在怀孕的前19天，每天给雌性Wistar大鼠注射不同剂量的氯化镉。高暴露组动物的胎盘重量减轻，并且在胎儿血管周围基底膜中的胶原蛋白含量以及胎儿血管的相对体积密度方面出现了一些轻度显微镜下的变化。这些结果与在吸烟母亲的胎盘中发现的变化一致，这可能是由于香烟烟雾中的镉所致。