镉对胎盘结构的影响。

Influence of cadmium on placental structure.

作者信息

Peereboom-Stegeman J H, van der Velde W J, Dessing J W

出版信息

Ecotoxicol Environ Saf. 1983 Feb;7(1):79-86. doi: 10.1016/0147-6513(83)90051-9.

PMID:6851928

Abstract

Placentas of smoking and nonsmoking mothers have been investigated with light microscopical techniques. The cadmium content of the same placentas had been determined in a previous study by means of atomic absorption spectrophotometry (AAS). The cadmium content of the placentas from smokers was found to be elevated, compared to that of nonsmokers. The volume density of the vascular bed in the terminal villi of the placentas of smokers was found to be decreased. Preliminary results of experiments in course with rats exposed to 0.2 mg CdCl2/kg body wt/day (by subcutaneous injection) seem to indicate that in the placenta of rats, the volume density of the blood vessels in the placental stroma is likewise reduced in the exposed animals.

摘要

已使用光学显微镜技术对吸烟和不吸烟母亲的胎盘进行了研究。在先前的一项研究中，已通过原子吸收分光光度法（AAS）测定了相同胎盘的镉含量。结果发现，与不吸烟者相比，吸烟者胎盘的镉含量升高。还发现，吸烟者胎盘终末绒毛中血管床的体积密度降低。对每天皮下注射0.2 mg CdCl₂/kg体重的大鼠进行的实验初步结果似乎表明，在暴露大鼠的胎盘中，胎盘基质中血管的体积密度同样降低。