Yang Shuhan, Zhang Hua, Shi Li, Yang Yang, Lu Yonghao, Qiu Weiyu, Fukuzawa Ii, Zhou Lifei, Xin Xiyan, Ding Ning, Luo Liyan, Wang Wei, Zhang Haolin
Department of Traditional Chinese Medicine, Peking University Third Hospital, Beijing, 100191, China.
State Key Laboratory of Female Fertility Promotion, Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China.
BMC Endocr Disord. 2025 Mar 24;25(1):77. doi: 10.1186/s12902-025-01898-0.
Previous studies have shown a correlation between ABO blood type and the occurrence of certain diseases. However, there is limited research on the potential association between ABO blood group and polycystic ovary syndrome (PCOS). This study aims to investigate the potential connection between ABO blood type and the regularity of menstrual cycles, menstrual bleeding level, and additional metabolic indicators among individuals diagnosed with PCOS.
This cross-sectional study involved 312 PCOS patients and 133 healthy controls whose menstruation and blood type were investigated by questionnaires. Their blood lipid content and hormone levels were also measured. We assessed the association between ABO blood type distribution in different groups and the occurrence of menstrual conditions in PCOS patients.
445 women participated in the study. There was a statistically significant difference in ABO blood type distribution among PCOS patients with varying menstrual levels (P = 0.036). Compared with other blood type groups, PCOS patients with blood type O exhibited statistically significant differences in BMI (P = 0.033), E2 levels (P < 0.001), LH levels (P = 0.022), and FSH levels (P < 0.001), and showed a higher tendency towards greater menstrual bleeding.
There exists a correlation between ABO blood type and menstrual bleeding level among PCOS patients. In particular, individuals with blood type O display a heightened likelihood of experiencing greater menstrual bleeding with more favorable endocrine status compared to non-O blood types in the population.
ClinicalTrials.gov NCT04264832 ( https://clinicaltrials.gov ). Registered on February 7, 2020.
既往研究表明ABO血型与某些疾病的发生之间存在关联。然而，关于ABO血型与多囊卵巢综合征（PCOS）之间潜在关联的研究有限。本研究旨在调查ABO血型与被诊断为PCOS的个体的月经周期规律性、月经出血量以及其他代谢指标之间的潜在联系。
这项横断面研究纳入了312例PCOS患者和133例健康对照者，通过问卷调查对其月经情况和血型进行了调查。还测量了他们的血脂含量和激素水平。我们评估了不同组中ABO血型分布与PCOS患者月经状况发生之间的关联。
445名女性参与了本研究。月经水平不同的PCOS患者中ABO血型分布存在统计学显著差异（P = 0.036）。与其他血型组相比，O型血的PCOS患者在BMI（P = 0.033）、E2水平（P < 0.001）、LH水平（P = 0.022）和FSH水平（P < 0.001）方面存在统计学显著差异，并且月经出血量倾向更高。
PCOS患者的ABO血型与月经出血量之间存在关联。特别是，与人群中的非O型血相比，O型血个体出现更多月经出血且内分泌状态更有利的可能性更高。
ClinicalTrials.gov NCT04264832（https://clinicaltrials.gov）。于2020年2月7日注册。
