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是时候考虑将强力霉素用于淋巴丝虫病的标准治疗了吗?关于使用强力霉素作为卫生方案辅助药物的新证据。

Time to consider doxycycline in the standard treatment of lymphatic filariasis? Emerging evidence on use of doxycycline as an adjunct to hygiene protocols.

作者信息

Kakakhel Mian Zahid Jan, Rath Shree, Sheraz Maheen, Rathi Diya, Ahmed Raheel

机构信息

Rehman Medical College, Peshawar, Khyber Pakhtunkhwa, Pakistan.

All India Institute of Medical Sciences, Bhubaneswar, India.

出版信息

Trop Med Health. 2025 Mar 24;53(1):39. doi: 10.1186/s41182-025-00726-4.

DOI:10.1186/s41182-025-00726-4
PMID:40122880
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11931818/
Abstract

With lymphatic filariasis being a rampant condition in tropical countries, multiple treatment modalities are being explored for their efficacy and practicability of use in low resource settings. Doxycycline, a commonly available drug across the world, has been proposed to improve patient status in those suffering with lymphatic filariasis. In conjunct with hygiene protocols, emerging trials have highlighted the success of doxycycline as an add-on drug. In this letter, we highlight the major findings in recent trials, and the scope of integrating doxycycline into national elimination strategies against filariasis.

摘要

由于淋巴丝虫病在热带国家肆虐,人们正在探索多种治疗方法,以评估其在资源匮乏地区使用的有效性和实用性。多西环素是一种在全球普遍可得的药物,已被提议用于改善淋巴丝虫病患者的状况。结合卫生协议,新出现的试验突出了多西环素作为附加药物的成功。在这封信中,我们强调了近期试验的主要发现,以及将多西环素纳入国家丝虫病消除战略的范围。

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Time to consider doxycycline in the standard treatment of lymphatic filariasis? Emerging evidence on use of doxycycline as an adjunct to hygiene protocols.是时候考虑将强力霉素用于淋巴丝虫病的标准治疗了吗?关于使用强力霉素作为卫生方案辅助药物的新证据。
Trop Med Health. 2025 Mar 24;53(1):39. doi: 10.1186/s41182-025-00726-4.
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Elimination of lymphatic filariasis: do we have the drugs to complete the job?消除淋巴丝虫病:我们有完成这项工作的药物吗?
Curr Opin Infect Dis. 2010 Dec;23(6):617-20. doi: 10.1097/QCO.0b013e32833fdee5.
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本文引用的文献

1
Adherence to Hygiene Protocols and Doxycycline Therapy in Ameliorating Lymphatic Filariasis Morbidity in an Endemic Area Post-Interruption of Disease Transmission in Ghana.在加纳疾病传播中断后,为改善流行地区淋巴丝虫病的发病率,坚持卫生协议和强力霉素治疗的效果。
Am J Trop Med Hyg. 2024 Oct 1;111(4_Suppl):66-82. doi: 10.4269/ajtmh.24-0313.
2
Efficacy of Intensified Hygiene Measures with or without the Addition of Doxycycline in the Management of Filarial Lymphedema: A Randomized Double-Blind, Placebo-Controlled Clinical Trial in Tanzania.在丝虫性淋巴水肿管理中强化卫生措施(加或不加强力霉素)的疗效:坦桑尼亚的一项随机双盲、安慰剂对照临床试验
Am J Trop Med Hyg. 2024 Aug 27;111(4_Suppl):33-51. doi: 10.4269/ajtmh.24-0049. Print 2024 Oct 1.
3
Repurposed Drugs That Activate Autophagy in Filarial Worms Act as Effective Macrofilaricides.可激活丝虫自噬的重新利用药物可作为有效的杀成虫剂。
Pharmaceutics. 2024 Feb 9;16(2):256. doi: 10.3390/pharmaceutics16020256.
4
The design and development of a multicentric protocol to investigate the impact of adjunctive doxycycline on the management of peripheral lymphoedema caused by lymphatic filariasis and podoconiosis.设计和开发一项多中心方案,以研究辅助使用多西环素对丝虫病和 Podoconiosis 引起的外周淋巴水肿管理的影响。
Parasit Vectors. 2020 Mar 30;13(1):155. doi: 10.1186/s13071-020-04024-2.
5
Anti- therapy for onchocerciasis & lymphatic filariasis: Current perspectives.抗丝虫病和淋巴丝虫病治疗:当前观点。
Indian J Med Res. 2019 Jun;149(6):706-714. doi: 10.4103/ijmr.IJMR_454_17.
6
Doxycycline improves filarial lymphedema independent of active filarial infection: a randomized controlled trial.多西环素可改善丝虫性淋巴水肿,与活动性丝虫感染无关:一项随机对照试验。
Clin Infect Dis. 2012 Sep;55(5):621-30. doi: 10.1093/cid/cis486. Epub 2012 May 18.
7
A single dose of doxycycline in combination with diethylcarbamazine for treatment of bancroftian filariasis.单剂量强力霉素联合乙胺嗪治疗班氏丝虫病。
Southeast Asian J Trop Med Public Health. 2010 Jul;41(4):800-12.
8
Lymphoedema: an underestimated health problem.淋巴水肿:一个被低估的健康问题。
QJM. 2003 Oct;96(10):731-8. doi: 10.1093/qjmed/hcg126.