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从长期使用米诺环素到色素沉着性单叶主动脉瓣：一例独特病例

From Chronic Use of Minocycline to Pigmented Unicuspid Aortic Valve: A Unique Single Case.

作者信息

Odeh Nour B, Farina Juan M, Manchen Pete J, Sell-Dottin Kristen A, Barrus Bryan

机构信息

Mayo Clinic, Phoenix, Arizona, US.

出版信息

Methodist Debakey Cardiovasc J. 2025 Mar 19;21(1):30-34. doi: 10.14797/mdcvj.1564. eCollection 2025.

DOI:10.14797/mdcvj.1564
PMID:40123942
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11927672/
Abstract

We discuss the case of a 47-year-old female who presented to our institution with progressive exertional shortness of breath. Her history was notable for severe acne medicated with 100 mg oral daily minocycline for 2 years and a presumptive diagnosis of a bicuspid aortic valve. Investigations revealed severe aortic stenosis, prompting a decision for elective aortic valve repair. Intraoperatively, significant calcification of a unicuspid aortic valve, atypically blackened valve, and endocardium of the left ventricle and aorta were visualized.

摘要

我们讨论了一名47岁女性的病例，该患者因进行性劳力性气短前来我院就诊。她的病史值得注意的是，曾因重度痤疮每日口服100毫克米诺环素治疗2年，且初步诊断为二叶式主动脉瓣。检查发现严重的主动脉瓣狭窄，促使决定进行择期主动脉瓣修复术。术中可见单叶式主动脉瓣显著钙化、瓣膜非典型变黑以及左心室和主动脉的内膜。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c32b/11927672/df6273dcc490/mdcvj-21-1-1564-g3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c32b/11927672/f89194633321/mdcvj-21-1-1564-g1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c32b/11927672/2ed39f5a7335/mdcvj-21-1-1564-g2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c32b/11927672/df6273dcc490/mdcvj-21-1-1564-g3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c32b/11927672/f89194633321/mdcvj-21-1-1564-g1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c32b/11927672/2ed39f5a7335/mdcvj-21-1-1564-g2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c32b/11927672/df6273dcc490/mdcvj-21-1-1564-g3.jpg

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本文引用的文献

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Surgical management of calcific valvular and coronary disease in a patient with alkaptonuria: a case report.一名患尿黑酸尿症患者钙化瓣膜及冠状动脉疾病的外科治疗：病例报告
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Interact Cardiovasc Thorac Surg. 2014 Aug;19(2):339-40. doi: 10.1093/icvts/ivu142. Epub 2014 May 13.
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