Wang Bowen, Peng Mengjia, Kou Guoyong, Fang Fei, Gao Jinhang
Department of Gastroenterology, West China Hospital, Sichuan University, Chengdu, China.
Department of Emergency, General Hospital of Tibet Military Command, Lhasa, China.
Front Physiol. 2025 Mar 7;16:1546307. doi: 10.3389/fphys.2025.1546307. eCollection 2025.
Acute mountain sickness (AMS) is a common condition following rapid exposure to high altitude, though severe complications such as acute gastrointestinal bleeding, systemic inflammatory response syndrome (SIRS) and multiple organ dysfunction syndrome (MODS) are rare. Herein, we report a case of SIRS and MODS in a young traveler who visited Lhasa, Tibet (elevation 3,650 m). Three days after arrival, the patient developed headache, abdominal pain, significant hematemesis, and persistent hypotension. Gastroscopy revealed diffuse bleeding of the gastric mucosa. Laboratory tests indicated multi-organ dysfunction involving the lungs, liver, and kidneys. The patient responded well to conservative treatment of continuous oxygen supplementation. This case represents one of the first reported instances of acute gastric mucosal injury and MODS induced by AMS, underscoring the significant medical risks associated with high-altitude environments.
急性高原病（AMS）是快速暴露于高海拔环境后常见的病症，不过诸如急性胃肠道出血、全身炎症反应综合征（SIRS）和多器官功能障碍综合征（MODS）等严重并发症较为罕见。在此，我们报告一例发生在一名前往西藏拉萨（海拔3650米）的年轻旅行者身上的SIRS和MODS病例。抵达三天后，患者出现头痛、腹痛、大量呕血及持续性低血压。胃镜检查显示胃黏膜弥漫性出血。实验室检查表明存在涉及肺、肝和肾的多器官功能障碍。患者对持续吸氧的保守治疗反应良好。该病例是首次报道的由AMS诱发的急性胃黏膜损伤和MODS病例之一，凸显了与高海拔环境相关的重大医疗风险。
