Wang Zehua, Zhang Ye, Ma Ning, Qiao Huiting, Xia Meiyun, Li Deyu
School of Biological Science and Medical Engineering, Key Laboratory of Biomechanics and Mechanobiology (Beihang University), Ministry of Education, Beijing Advanced Innovation Center for Biomedical Engineering, Beihang University, Beijing, China.
Innovation Center for Medical Engineering &Engineering Medicine, Hangzhou International Innovation Institute, Beihang University, Hangzhou, China.
J Alzheimers Dis Rep. 2025 Mar 21;9:25424823251325537. doi: 10.1177/25424823251325537. eCollection 2025 Jan-Dec.
Whether there is a cognitive load-dependent brain activation pattern in the pre-Alzheimer's disease phase is unknown. Multimodal system provides a powerful technical tool.
We evaluated brain activity patterns under different cognitive loads in patients with mild cognitive impairment.
Functional near-infrared spectroscopy signals and electroencephalography signals were acquired from the mild cognitive impairment group (MCI, n = 20) and the healthy control group (HC, n = 24) under four cognitive loads. We analyzed the respective brain activity features and performed correlation analyses.
(1) During the encoding phase, both the left occipital ( = 0.05, < 0.01) and left temporal ( = 0.02, = 0.03) skewness condition effects and between-group effects were significant. (2) As the cognitive load increased, the clustering coefficients and local efficiencies were significantly lower for the HC group. (3) The left occipital and left temporal activation skewness in the MCI group were significantly correlated with left occipital electrical features, whereas the left occipital activation intensity and skewness were significantly correlated with left occipital electrical features in HC group.
The pattern of brain activity in MCI depends on cognitive load. Left occipital and left temporal may be important brain regions for evaluating MCI and need to be focused on in the future.
在阿尔茨海默病前期是否存在认知负荷依赖的脑激活模式尚不清楚。多模态系统提供了一个强大的技术工具。
我们评估了轻度认知障碍患者在不同认知负荷下的脑活动模式。
在四种认知负荷下，从轻度认知障碍组（MCI，n = 20）和健康对照组（HC，n = 24）采集功能近红外光谱信号和脑电图信号。我们分析了各自的脑活动特征并进行了相关性分析。
（1）在编码阶段，左枕叶（ = 0.05， < 0.01）和左颞叶（ = 0.02， = 0.03）的偏态条件效应和组间效应均显著。（2）随着认知负荷增加，HC组的聚类系数和局部效率显著降低。（3）MCI组左枕叶和左颞叶激活偏态与左枕叶电特征显著相关，而HC组左枕叶激活强度和偏态与左枕叶电特征显著相关。
MCI患者的脑活动模式取决于认知负荷。左枕叶和左颞叶可能是评估MCI的重要脑区，未来需要重点关注。
