Amendola B E, Amendola M A, McClatchey K D
Surg Gynecol Obstet. 1985 Jul;161(1):30-2.
A squamous cell carcinoma presented in a 20 year old female nonsmoker three years after receiving a high dosage of radiation therapy to the base of the skull, face and entire neuroaxis and intense combination chemotherapy for a parameningeal rhabdomyosarcoma of the paranasal sinuses is reported. The larynx received a dose of about 3,500 rads over an eight week period. This dosage in conjunction with the associated intense chemotherapy regimen given to the patient may explain the appearance of a radiation induced tumor in an unusually short latent period. This certainly represents a risk in young patients in whom an aggressive combined approach is taken and the physician should be aware of.
据报道，一名20岁不吸烟女性在接受针对颅底、面部及整个神经轴的高剂量放射治疗以及针对鼻窦脑膜旁横纹肌肉瘤的强化联合化疗三年后，出现了鳞状细胞癌。喉部在八周内接受了约3500拉德的剂量。该剂量与患者接受的相关强化化疗方案可能解释了在异常短的潜伏期出现放射诱发肿瘤的原因。这无疑是采用积极联合治疗方法的年轻患者面临的一种风险，医生应该对此有所警觉。
