重症监护病房中的唑类耐药情况 - Suppr

[Azole-resistant in Critical Care Units].

作者信息

Antona-Urieta Nerea, Barrios-Andrés Jose L, Seijas-Betolaza Iratxe, Higuera-Lucas Juan, Boado-Varela Victoria, López-Peralta Elena, Alcázar-Fuoli Laura, Zaragoza-Hernández Oscar, López-Soria Leyre M

机构信息

Hospital Universitario Cruces, Bilbao, España.

Laboratorio de Referencia e Investigación en Micología, Centro Nacional de Microbiología, Instituto de Salud Carlos III, España.

出版信息

Rev Esp Quimioter. 2025 Mar 24;38(3):240-243. doi: 10.37201/req/122.2024.

DOI:10.37201/req/122.2024

PMID:40125643

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12095932/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e9c/12095932/fc4766bb0621/revespquimioter-38-240-g001.jpg

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[Azole-resistant in Critical Care Units].重症监护病房中的唑类耐药情况

Rev Esp Quimioter. 2025 Mar 24;38(3):240-243. doi: 10.37201/req/122.2024.

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Genomic reconstruction of an azole-resistant Candida parapsilosis outbreak and the creation of a multi-locus sequence typing scheme: a retrospective observational and genomic epidemiology study.耐唑类近平滑念珠菌暴发的基因组重建及多位点序列分型方案的建立：一项回顾性观察与基因组流行病学研究

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Efficacy of LAMB against Emerging Azole- and Multidrug-Resistant Isolates in the Model.羔羊胃提取物维B12对模型中新兴唑类和多药耐药菌株的疗效。

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Analysis of global antifungal surveillance results reveals predominance of Erg11 Y132F alteration among azole-resistant Candida parapsilosis and Candida tropicalis and country-specific isolate dissemination.全球抗真菌监测结果分析显示，唑类耐药近平滑念珠菌和热带念珠菌中以 Erg11 Y132F 改变为主，且存在特定国家分离株的传播。

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Species distribution, azole resistance and related molecular mechanisms in invasive Candida parapsilosis complex isolates: Increase in fluconazole resistance in 21 years.侵袭性近平滑念珠菌复合体分离株的物种分布、唑类耐药性及相关分子机制：21 年来氟康唑耐药性的增加。

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The S862C amino acid change in CpMrr1 confers fluconazole resistance in .CpMrr1中的S862C氨基酸变化赋予了对氟康唑的抗性。

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Loss of C-5 Sterol Desaturase Activity Results in Increased Resistance to Azole and Echinocandin Antifungals in a Clinical Isolate of Candida parapsilosis.C-5 甾醇去饱和酶活性缺失导致临床分离近平滑念珠菌对唑类和棘白菌素类抗真菌药物的耐药性增加。

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Clin Microbiol Infect. 2017 Aug;23(8):575.e1-575.e8. doi: 10.1016/j.cmi.2017.02.002. Epub 2017 Feb 11.

本文引用的文献

Fluconazole-resistant Candida parapsilosis genotypes from hospitals located in five Spanish cities and one in Italy: Description of azole-resistance profiles associated with the Y132F ERG11p substitution.来自西班牙五个城市和意大利一个城市医院的氟康唑耐药近平滑念珠菌基因型：与 Y132F ERG11p 取代相关的唑类耐药谱的描述。

Mycoses. 2024 Mar;67(3):e13706. doi: 10.1111/myc.13706.

Recent increase in fluconazole-nonsusceptible Candida parapsilosis in a global surveillance with the expansion of the Erg11 Y132F genotype and a rapid detection method for this alteration.全球监测显示，氟康唑不敏感近平滑念珠菌的比例增加，与 Erg11 Y132F 基因型的扩展以及该突变的快速检测方法有关。

Diagn Microbiol Infect Dis. 2023 Jul;106(3):115957. doi: 10.1016/j.diagmicrobio.2023.115957. Epub 2023 Apr 15.

Worldwide emergence of fluconazole-resistant Candida parapsilosis: current framework and future research roadmap.氟康唑耐药近平滑念珠菌的全球流行：现有框架与未来研究路线图。

Lancet Microbe. 2023 Jun;4(6):e470-e480. doi: 10.1016/S2666-5247(23)00067-8. Epub 2023 Apr 27.

Hospital Clonal Outbreak of Fluconazole-Resistant Candida parapsilosis Harboring the Y132F ERG11p Substitution in a French Intensive Care Unit.法国重症监护病房中一株携带 ERG11p Y132F 取代突变的氟康唑耐药近平滑假丝酵母菌的医院克隆性暴发

Antimicrob Agents Chemother. 2023 Mar 16;67(3):e0113022. doi: 10.1128/aac.01130-22. Epub 2023 Feb 28.

Global Emergence of Resistance to Fluconazole and Voriconazole in in Tertiary Hospitals in Spain During the COVID-19 Pandemic.西班牙三级医院在新冠疫情期间氟康唑和伏立康唑耐药性的全球出现情况

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Fluconazole-resistant Candida parapsilosis clonally related genotypes: first report proving the presence of endemic isolates harbouring the Y132F ERG11 gene substitution in Spain.氟康唑耐药近平滑念珠菌克隆相关基因型：首次报道证明在西班牙存在携带 ERG11 基因 Y132F 取代的地方性分离株。

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[Azole-resistant in Critical Care Units].

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