法国重症监护病房中一株携带 ERG11p Y132F 取代突变的氟康唑耐药近平滑假丝酵母菌的医院克隆性暴发
Hospital Clonal Outbreak of Fluconazole-Resistant Candida parapsilosis Harboring the Y132F ERG11p Substitution in a French Intensive Care Unit.
机构信息
Medical and infectious diseases ICU, APHP, Bichat hospital, Paris, France.
Laboratoire de parasitologie mycologie, AP-HP, Hôpital Bichat Claude Bernard, Paris, France.
出版信息
Antimicrob Agents Chemother. 2023 Mar 16;67(3):e0113022. doi: 10.1128/aac.01130-22. Epub 2023 Feb 28.
Abstract
We report the first identification of a fluconazole-resistant Candida parapsilosis (FR-) strain in our hospital, which subsequently caused an outbreak involving 17 patients (12 deaths) within a 26-bed French intensive care unit. Microsatellite genotyping confirmed that all FR- isolates belonged to the same clone. Given recent reports of rapid dissemination of these emerging clones, routine testing of azole susceptibility for all Candida parapsilosis isolates should be encouraged, at least in ICU patients.
摘要
我们报告了我院首例氟康唑耐药近平滑念珠菌（FR-）菌株的鉴定，该菌株随后导致了一个涉及 17 名患者（12 例死亡）的爆发，该爆发发生在一个拥有 26 张床位的法国重症监护病房。微卫星基因分型证实所有 FR-分离株均属于同一克隆。鉴于最近这些新兴克隆的快速传播的报道，应鼓励对所有近平滑念珠菌分离株进行唑类药物敏感性常规检测，至少应在 ICU 患者中进行。
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