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法国重症监护病房中一株携带 ERG11p Y132F 取代突变的氟康唑耐药近平滑假丝酵母菌的医院克隆性暴发

Hospital Clonal Outbreak of Fluconazole-Resistant Candida parapsilosis Harboring the Y132F ERG11p Substitution in a French Intensive Care Unit.

机构信息

Medical and infectious diseases ICU, APHP, Bichat hospital, Paris, France.

Laboratoire de parasitologie mycologie, AP-HP, Hôpital Bichat Claude Bernard, Paris, France.

出版信息

Antimicrob Agents Chemother. 2023 Mar 16;67(3):e0113022. doi: 10.1128/aac.01130-22. Epub 2023 Feb 28.

DOI:10.1128/aac.01130-22
PMID:36853002
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10019182/
Abstract

We report the first identification of a fluconazole-resistant Candida parapsilosis (FR-) strain in our hospital, which subsequently caused an outbreak involving 17 patients (12 deaths) within a 26-bed French intensive care unit. Microsatellite genotyping confirmed that all FR- isolates belonged to the same clone. Given recent reports of rapid dissemination of these emerging clones, routine testing of azole susceptibility for all Candida parapsilosis isolates should be encouraged, at least in ICU patients.

摘要

我们报告了我院首例氟康唑耐药近平滑念珠菌（FR-）菌株的鉴定，该菌株随后导致了一个涉及 17 名患者（12 例死亡）的爆发，该爆发发生在一个拥有 26 张床位的法国重症监护病房。微卫星基因分型证实所有 FR-分离株均属于同一克隆。鉴于最近这些新兴克隆的快速传播的报道，应鼓励对所有近平滑念珠菌分离株进行唑类药物敏感性常规检测，至少应在 ICU 患者中进行。

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Fluconazole-resistant Candida parapsilosis clonally related genotypes: first report proving the presence of endemic isolates harbouring the Y132F ERG11 gene substitution in Spain.氟康唑耐药近平滑念珠菌克隆相关基因型：首次报道证明在西班牙存在携带 ERG11 基因 Y132F 取代的地方性分离株。
Clin Microbiol Infect. 2022 Aug;28(8):1113-1119. doi: 10.1016/j.cmi.2022.02.025. Epub 2022 Apr 16.
2
Etest ECVs/ECOFFs for Detection of Resistance in Prevalent and Three Nonprevalent spp. to Triazoles and Amphotericin B and Aspergillus spp. to Caspofungin: Further Assessment of Modal Variability.Etest 检测流行与三种非流行 种对唑类和两性霉素 B 以及曲霉菌属对卡泊芬净的耐药性的 ECVs/ECOFFs：模态变异性的进一步评估。
Antimicrob Agents Chemother. 2021 Oct 18;65(11):e0109321. doi: 10.1128/AAC.01093-21. Epub 2021 Aug 9.
3
Environmental Clonal Spread of Azole-Resistant with Erg11-Y132F Mutation Causing a Large Candidemia Outbreak in a Brazilian Cancer Referral Center.在巴西一家癌症转诊中心，具有Erg11-Y132F突变的耐唑类念珠菌的环境克隆传播引发了大规模念珠菌血症暴发。
J Fungi (Basel). 2021 Mar 30;7(4):259. doi: 10.3390/jof7040259.
4
Hospital outbreak of fluconazole-resistant : arguments for clonal transmission and long-term persistence.医院内氟康唑耐药性的暴发：克隆传播及长期持续存在的证据
Antimicrob Agents Chemother. 2023 May 1;95(5). doi: 10.1128/AAC.02036-20. Epub 2021 Feb 16.
5
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7
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