Lorentzen J E, Nielsen O M, Arendrup H, Kimose H H, Bille S, Andersen J, Jensen C H, Jacobsen F, Røder O C
Surgery. 1985 Jul;98(1):81-6.
Among 2411 consecutive arterial reconstructions performed with synthetic prosthetic material in Denmark during a 4-year period, 62 patients (2.6%) developed graft infection. Graft infection occurred only when the groin had been incised. The incidence of infection and the spread of infection along the graft did not relate to the graft material used (Dacron velour, Dacron woven, polytetrafluoroethylene, and umbilical vein). Retrospective analysis disclosed predisposing or precipitating factors in 50 of the 62 cases; the most important seemed to be unsatisfactory surgical technique. Fifty-three percent of the graft infections occurred within 30 days. Gram-positive cocci were the most common pathogen. The 62 patients had been in the hospital for a mean of 90 days and had undergone an average of 1.4 operations for graft infections. Of the patients, 25.8% died and 30.6% underwent amputations. Vascular graft infection is still one of the major problems in vascular surgery; greater care should be taken to improve antiseptics, improve surgical technique, and establish a rational prophylactic antibiotic regimen. A prophylactic antibiotic regimen of a combination of cephalosporin and ampicillin is recommended.
在丹麦4年期间用合成假体材料进行的2411例连续动脉重建手术中，62例患者（2.6%）发生了移植物感染。移植物感染仅在腹股沟切开时发生。感染发生率及感染沿移植物的扩散与所用移植物材料（涤纶绒、编织涤纶、聚四氟乙烯和脐静脉）无关。回顾性分析显示62例中有50例存在易感因素或促发因素；最重要的似乎是手术技术欠佳。53%的移植物感染发生在30天内。革兰氏阳性球菌是最常见的病原体。这62例患者平均住院90天，因移植物感染平均接受了1.4次手术。患者中25.8%死亡，30.6%接受了截肢手术。血管移植物感染仍然是血管外科的主要问题之一；应更加注意改进抗菌措施、提高手术技术并建立合理的预防性抗生素方案。推荐使用头孢菌素和氨苄西林联合的预防性抗生素方案。
