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重症急性胰腺炎大鼠甲状腺的结构与功能变化

The Structure and Functional Changes of Thyroid in Severe Acute Pancreatitis Rats.

作者信息

Yang B, Qiao H, Liu Y, Wang X, Peng W

机构信息

Department of Cardiac Surgery, Beijing Anzhen Hospital, Capital Medical University, Beijing, China. Department of Pharmacy, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.

出版信息

Physiol Res. 2025 Mar 24;74(1):105-114. doi: 10.33549/physiolres.935403.

DOI:10.33549/physiolres.935403
PMID:40126147
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11995943/
Abstract

Severe acute pancreatitis (SAP) is associated with metabolic disorders, hypocalcemia, and multiple organ failure. The objective of this study was to investigate changes in thyroid ultrastructure and function in rats with SAP and to provide a theoretical basis for the clinical treatment of thyroid injury in patients with SAP. 64 male SPF Wistar rats were randomly divided into the SAP group and the control group. Pancreatic enzymatic indicators and thyroid hormones were detected, pathology scores were evaluated, and morphological changes were observed under light microscopy and transmission electron microscopy (TEM) in both groups. The serum levels of triiodothyronine (T3), tetraiodothyronine (T4) and Ca2+ were significantly lower in the SAP group than in the control group (P<0.05), whereas the level of calcitonin (CT) was significantly higher than that in the control group (P<0.05). The thyroid structure (pathology and electron microscopy) of the SAP rats was seriously damaged and worsened over time. SAP can cause thyroid injury through a variety of mechanisms, which can also retroact to pancreatitis to aggravate the inflammatory response. This study may have theoretical significance for basic research on SAP. Key words Severe acute pancreatitis, Thyroid, Structure and functional changes, Transmission electron microscopy.

摘要

重症急性胰腺炎（SAP）与代谢紊乱、低钙血症及多器官功能衰竭相关。本研究旨在探讨SAP大鼠甲状腺超微结构及功能的变化，为临床治疗SAP患者的甲状腺损伤提供理论依据。将64只雄性SPF级Wistar大鼠随机分为SAP组和对照组。检测两组的胰腺酶指标和甲状腺激素，评估病理评分，并在光镜和透射电镜（TEM）下观察形态学变化。SAP组血清三碘甲状腺原氨酸（T3）、甲状腺素（T4）和Ca2+水平显著低于对照组（P<0.05），而降钙素（CT）水平显著高于对照组（P<0.05）。SAP大鼠的甲状腺结构（病理及电镜）严重受损，且随时间推移而加重。SAP可通过多种机制导致甲状腺损伤，甲状腺损伤也可反作用于胰腺炎，加重炎症反应。本研究可能对SAP的基础研究具有理论意义。关键词 重症急性胰腺炎，甲状腺，结构和功能变化，透射电镜

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本文引用的文献

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Acute Pancreatitis: Diagnosis and Treatment.急性胰腺炎：诊断与治疗。
Drugs. 2022 Aug;82(12):1251-1276. doi: 10.1007/s40265-022-01766-4. Epub 2022 Sep 8.
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Vitamin D Treatment Alters Thyroid Functional Morphology in Orchidectomized Rat Model of Osteoporosis.维生素 D 治疗改变去势骨质疏松症大鼠模型的甲状腺功能形态。
Int J Mol Sci. 2022 Jan 12;23(2):791. doi: 10.3390/ijms23020791.
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A variant in the CASR gene (c.368T>C) causing hypocalcemia refractory to standard medical therapy.钙敏感受体（CASR）基因中的一个变体（c.368T>C）导致对标准药物治疗难治的低钙血症。
Endocrinol Diabetes Metab Case Rep. 2021 Dec 1;2021. doi: 10.1530/EDM-21-0005.
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Heterogeneity of G protein activation by the calcium-sensing receptor.钙敏感受体对 G 蛋白激活的异质性。
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Int Immunopharmacol. 2020 Oct;87:106771. doi: 10.1016/j.intimp.2020.106771. Epub 2020 Jul 16.
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Int Immunopharmacol. 2020 Mar 3;82:106342. doi: 10.1016/j.intimp.2020.106342.
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