Ross Andrew, Shaw Rebecca J, Garth Louise, Farrelly Cathy
Liverpool University Hospital NHS Foundation Trust, Liverpool L7 8XP, UK.
Department of Clinical Infection, Microbiology and Immunology, Institute of Infection, Veterinary and Ecological Sciences, Leahurst Campus, University of Liverpool, Liverpool CH64 7TEK, UK.
Hematol Rep. 2025 Feb 21;17(2):10. doi: 10.3390/hematolrep17020010.
Acquired factor X (FX) deficiency is a rare condition that can cause life threatening bleeding. Here we outline a successful management strategy for gastrointestinal bleeding (GI) using human FX concentrate.
A 61-year-old male presented with upper GI bleeding and a prolonged prothrombin time. Investigations demonstrated an acquired FX deficiency (determined to be secondary to AL amyloidosis).
Treatment with FX concentrate to maintain trough FX levels >20% resulted in successful cessation of bleeding symptoms, and levels >50% facilitated urgent invasive procedures.
This case report adds valuable insight into the management of this rare condition, and how best to utilize FX concentrates in acquired FX deficiency.
获得性因子X（FX）缺乏症是一种罕见的疾病，可导致危及生命的出血。在此，我们概述了一种使用人FX浓缩物治疗胃肠道出血（GI）的成功管理策略。
一名61岁男性出现上消化道出血，凝血酶原时间延长。检查显示为获得性FX缺乏症（确定为继发于AL淀粉样变性）。
用FX浓缩物治疗以维持谷值FX水平>20%，成功停止了出血症状，而水平>50%则有助于进行紧急侵入性操作。
本病例报告为这种罕见疾病的管理以及如何在获得性FX缺乏症中最佳利用FX浓缩物提供了宝贵的见解。
