2024年美国胸科学会BEAR Cage获奖提案：用于急性呼吸窘迫综合征的内皮靶向信使核糖核酸脂质纳米颗粒 - Suppr

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2024 American Thoracic Society BEAR Cage Winning Proposal: Endothelial-targeted mRNA Lipid Nanoparticles for Acute Respiratory Distress Syndrome.

作者信息

Essien Eno-Obong I

机构信息

Division of Pulmonary and Critical Care Medicine University of Pennsylvania Philadelphia, Pennsylvania.

出版信息

Am J Respir Crit Care Med. 2025 Jun;211(6):915-917. doi: 10.1164/rccm.202412-2442ED.

DOI:10.1164/rccm.202412-2442ED

PMID:40126367

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12175921/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d22/12175921/f9d5b570c7da/rccm.202412-2442EDf1.jpg

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Marginated Neutrophils in the Lungs Effectively Compete for Nanoparticles Targeted to the Endothelium, Serving as a Part of the Reticuloendothelial System.肺部边缘中性粒细胞有效地与靶向内皮的纳米颗粒竞争，作为网状内皮系统的一部分。

ACS Nano. 2024 Aug 20;18(33):22275-22297. doi: 10.1021/acsnano.4c06286. Epub 2024 Aug 6.

Pulmonary drug delivery for acute respiratory distress syndrome.肺部给药治疗急性呼吸窘迫综合征。

Pulm Pharmacol Ther. 2023 Apr;79:102196. doi: 10.1016/j.pupt.2023.102196. Epub 2023 Jan 20.

Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine.mRNA-1273 新型冠状病毒疫苗的有效性和安全性。

N Engl J Med. 2021 Feb 4;384(5):403-416. doi: 10.1056/NEJMoa2035389. Epub 2020 Dec 30.

Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine.BNT162b2 mRNA 新冠病毒疫苗的安全性和有效性。

N Engl J Med. 2020 Dec 31;383(27):2603-2615. doi: 10.1056/NEJMoa2034577. Epub 2020 Dec 10.

Acute respiratory distress syndrome.急性呼吸窘迫综合征。

Nat Rev Dis Primers. 2019 Mar 14;5(1):18. doi: 10.1038/s41572-019-0069-0.

The Lung Microvasculature Is a Functional Immune Niche.肺微血管是功能性免疫生态位。

Trends Immunol. 2018 Nov;39(11):890-899. doi: 10.1016/j.it.2018.09.002. Epub 2018 Sep 22.

The Lung is a Host Defense Niche for Immediate Neutrophil-Mediated Vascular Protection.肺是中性粒细胞介导的即时血管保护的宿主防御微环境。

Sci Immunol. 2017 Apr 28;2(10). doi: 10.1126/sciimmunol.aam8929.

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JAMA. 2016 Feb 23;315(8):788-800. doi: 10.1001/jama.2016.0291.

New Strategies for Effective Therapeutics in Critically Ill Patients.重症患者有效治疗的新策略

JAMA. 2016 Feb 23;315(8):747-8. doi: 10.1001/jama.2016.0661.

Endothelial nanomedicine for the treatment of pulmonary disease.用于治疗肺部疾病的内皮纳米医学

Expert Opin Drug Deliv. 2015 Feb;12(2):239-61. doi: 10.1517/17425247.2015.961418. Epub 2014 Nov 14.

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