Harlap S, Shiono P H, Ramcharan S, Golbus M, Bachman R, Mann J, Lewis J P
Teratology. 1985 Jun;31(3):381-7. doi: 10.1002/tera.1420310309.
Chromosomal abnormalities were studied in 33,551 abortions and births to women whose contraceptive histories had been recorded at their first antenatal visit in 1975-1977. Chromosome examinations were performed exclusively on clinical grounds. There were 45 de novo abnormalities detected (1.34/1,000); three of them were detected at amniocentesis. Trisomy 21 was observed in 27 cases (0.80/1,000), trisomy 18 in nine (0.27), other trisomies in three (0.09), and translocations or deletions in five (0.15). One case of triploidy and six cases of inherited abnormalities were detected. There were no significant racial variations. No increase in risk for chromosomal abnormalities was found among women who had used oral contraceptives prior to becoming pregnant or among women who experienced oral contraceptive breakthrough pregnancies. Two cases of trisomy 18 were observed among the 814 deliveries following oral contraceptive breakthrough conceptions (2.46/1,000), two cases of trisomy 21 occurred in 338 births following failures of rhythm contraception (5.92/1,000), and no cases of trisomy 21 or 18 among the 1,569 women using spermicides at the time of conception.
对1975 - 1977年首次产前检查时记录了避孕史的妇女的33551例流产和分娩进行了染色体异常研究。染色体检查完全基于临床原因进行。共检测到45例新发异常（1.34/1000）；其中3例在羊膜穿刺术中检测到。21三体综合征观察到27例（0.80/1000），18三体综合征9例（0.27），其他三体综合征3例（0.09），易位或缺失5例（0.15）。检测到1例三倍体和6例遗传异常。无显著种族差异。在怀孕前使用口服避孕药的妇女或经历口服避孕药突破性怀孕的妇女中，未发现染色体异常风险增加。在口服避孕药突破性受孕后的814例分娩中观察到2例18三体综合征（2.46/1000），在节律避孕失败后的338例分娩中有2例21三体综合征（5.92/1000），在受孕时使用杀精剂的1569名妇女中未发现21三体或18三体病例。
