Mohammadi Mehrdad
Department of Laboratory Technical Sciences Development, Gene Fanavaran Teb Azma Company, Isfahan, Iran.
Arch Virol. 2025 Mar 24;170(5):87. doi: 10.1007/s00705-025-06265-x.
Human bocaviruses (HBoVs), first identified in 2005 and composed of genotypes 1-4, have been increasingly detected worldwide in pediatric patients with acute gastroenteritis. HBoV-1 has been primarily associated with respiratory symptoms, while HBoV2-4 are mostly found in gastrointestinal (GI) samples. Results from case-control studies are still controversial; however, epidemiological evidence has shown a significant association between HBoV-2 and gastroenteritis. This review will primarily focus on this association, with a brief discussion of evidence related to other HBoV genotypes. Pathological and molecular studies on the pathogenesis of HBoV, particularly in GI cells, are very scarce, possibly due to the difficulties of in vitro HBoV culture. Nonetheless, some relevant findings from colorectal cancer samples have yielded valuable insights regarding the behavior of HBoV in the GI system. In the present review, we provide an updated overview of the epidemiological evidence for an association of HBoV infection with acute gastroenteritis and focus on the cellular and molecular perspectives of HBoV pathogenicity. Finally, we look at the knowledge gaps about how HBoV affects the GI system and explore future directions.
人博卡病毒（HBoV）于2005年首次被发现，由1-4型基因型组成，在全球范围内，越来越多地在患有急性肠胃炎的儿科患者中被检测到。HBoV-1主要与呼吸道症状相关，而HBoV2-4大多在胃肠道（GI）样本中被发现。病例对照研究的结果仍存在争议；然而，流行病学证据表明HBoV-2与肠胃炎之间存在显著关联。本综述将主要关注这种关联，并简要讨论与其他HBoV基因型相关的证据。关于HBoV发病机制的病理学和分子研究，特别是在胃肠道细胞中的研究非常稀少，这可能是由于体外培养HBoV存在困难。尽管如此，来自结直肠癌样本的一些相关发现为HBoV在胃肠道系统中的行为提供了有价值的见解。在本综述中，我们提供了关于HBoV感染与急性肠胃炎关联的流行病学证据的最新概述，并关注HBoV致病性的细胞和分子层面。最后，我们审视了关于HBoV如何影响胃肠道系统的知识空白，并探索未来的研究方向。
