McDonald T P, Miura M, Koizumi S
Thromb Res. 1985 May 15;38(4):353-9. doi: 10.1016/0049-3848(85)90134-3.
A thrombocytopoiesis-stimulating factor (TSF or thrombopoietin) was found to be significantly elevated in sera of a patient with chronic thrombocytopenia at one hour after infusion with fresh-frozen plasma (FFP). No detectable levels of TSF were found in the pre-infusion sera or in the infusate. At 2 hours post-infusion, TSF levels were decreased, and by 24 hrs the TSF titers were undetectable. Not only did FFP elevate TSF levels, but 6 days later significant increases in platelet counts were observed. This work confirms a previous finding of increased TSF levels following plasma infusion in a patient with similar clinical features and suggests that these patients lack a plasma factor that plays a critical role in TSF production.
在一名慢性血小板减少症患者输注新鲜冰冻血浆（FFP）一小时后，发现其血清中的血小板生成刺激因子（TSF或血小板生成素）显著升高。在输注前的血清或输注液中未检测到TSF水平。输注后2小时，TSF水平下降，到24小时时TSF滴度无法检测到。FFP不仅提高了TSF水平，而且6天后观察到血小板计数显著增加。这项工作证实了之前在一名具有相似临床特征的患者中输注血浆后TSF水平升高的发现，并表明这些患者缺乏在TSF产生中起关键作用的血浆因子。
