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窄谱中波紫外线在儿童皮肤科患者中的应用:一家三级医院的十年经验

Use of narrow-band ultraviolet B in pediatric dermatology patients: ten years of experience from a tertiary care hospital.

作者信息

Menteşoğlu Dilek, Kurmuş Gökçe Işıl, Kartal Selda Pelin

机构信息

Department of Dermatology and Venereology, Ankara Etlik City Hospital, Ankara, Turkey.

出版信息

Arch Dermatol Res. 2025 Mar 24;317(1):626. doi: 10.1007/s00403-025-04148-4.

DOI:10.1007/s00403-025-04148-4
PMID:40126705
Abstract

Narrow-band UVB (NB-UVB) phototherapy is a safe and effective treatment for pediatric skin disorders. We aimed to present the results of our 10-year experience of the efficacy and safety of NB-UVB phototherapy in children. We collected data from the phototherapy records of children aged < 17 years who received treatment between January 2013 and June 2023. The study included 108 patients, of whom 58 (53.7%) were female and 50 (46.3%) were male, with an average age of 12.6 years (range, 5-16 years). The most common skin diseases treated with NB-UVB phototherapy were psoriasis vulgaris (n = 40, 37.9%), vitiligo (n = 36, 33.3%), and guttate psoriasis (n = 12, 11.1%). The average duration of phototherapy for all patients was 5.88 months (ranging: 0.5-20.5 months), with a mean cumulative phototherapy dose of 29.0 J/cm. The cumulative phototherapy dose was 25.7 ± 29.1 J/cm for psoriasis vulgaris, 41.2 ± 34.5 J/cm for vitiligo, and 16.8 ± 10.9 J/cm for guttate psoriasis. Ninety-nine patients (91.7%) responded positively to phototherapy without significant side effects. Only 20 patients (18.5%) experienced mild and temporary adverse effects such as erythema, itching, and burning, which did not affect the treatment. Of the 108 patients, 73 (67.6%) did not require additional phototherapy sessions and 78 (72.2%) did not experience disease recurrence. NB-UVB phototherapy is an effective and safe treatment for skin diseases, particularly psoriasis and vitiligo, which can have severe psychological effects on children.

摘要

窄谱中波紫外线(NB-UVB)光疗是治疗儿童皮肤疾病的一种安全有效的方法。我们旨在呈现我们在儿童中应用NB-UVB光疗的疗效和安全性方面10年经验的结果。我们收集了2013年1月至2023年6月期间接受治疗的年龄小于17岁儿童的光疗记录数据。该研究包括108例患者,其中58例(53.7%)为女性,50例(46.3%)为男性,平均年龄为12.6岁(范围5 - 16岁)。接受NB-UVB光疗治疗的最常见皮肤疾病为寻常型银屑病(n = 40,37.9%)、白癜风(n = 36,33.3%)和点滴状银屑病(n = 12,11.1%)。所有患者的平均光疗持续时间为5.88个月(范围:0.5 - 20.5个月),平均累积光疗剂量为29.0 J/cm²。寻常型银屑病的累积光疗剂量为25.7±29.1 J/cm²,白癜风为41.2±34.5 J/cm²,点滴状银屑病为16.8±10.9 J/cm²。99例患者(91.7%)对光疗反应良好,且无明显副作用。仅20例患者(18.5%)出现如红斑、瘙痒和灼痛等轻度且短暂的不良反应,这些未影响治疗。在108例患者中,73例(67.6%)无需额外的光疗疗程,78例(72.2%)未出现疾病复发。NB-UVB光疗是治疗皮肤疾病,尤其是对儿童可能产生严重心理影响的银屑病和白癜风的一种有效且安全的治疗方法。

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本文引用的文献

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The psychosocial impacts of vitiligo, psoriasis, and alopecia areata on pediatric patients.白癜风、银屑病和斑秃对儿科患者的心理社会影响。
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Phototherapy in children: Epidemiology, clinical profile, and outcome.儿童光疗:流行病学、临床特征及结局
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Use of Phototherapy in Children.儿童光疗的应用
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