Castro G D, Castro J A
Toxicology. 1985 Jun 28;35(4):319-26. doi: 10.1016/0300-483x(85)90065-4.
Sprague-Dawley male rats were treated with either 100 mg/kg Nifurtimox or Benznidazole p.o. and pentane evolution was measured at different periods of time. No significant increase in pentane evolution was observed in animals treated with Benznidazole during periods of time up to 10 h. In animals treated with Nifurtimox, a significant increase in pentane evolution was observed at 10 h but not at 3 or 6 h. The pentane evolution effect of Nifurtimox was compared to that of carbon tetrachloride. The latter was very intense up to 1 h and ceased thereafter. The possible participation of lipid peroxidation in the unwanted toxic side effects of Nifurtimox and Benznidazole is discussed.
将100mg/kg硝呋替莫或苯硝唑经口给予雄性Sprague-Dawley大鼠，并在不同时间段测量戊烷释放量。在长达10小时的时间段内，给予苯硝唑治疗的动物未观察到戊烷释放量显著增加。在用硝呋替莫治疗的动物中，在10小时时观察到戊烷释放量显著增加，但在3或6小时时未观察到。将硝呋替莫的戊烷释放效应与四氯化碳的进行了比较。后者在1小时内非常强烈，此后停止。讨论了脂质过氧化在硝呋替莫和苯硝唑不良毒性副作用中的可能作用。
