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Mutagenicity of 2 anti-chagasic drugs and their metabolic deactivation.

作者信息

Nagel R, Nepomnaschy I

出版信息

Mutat Res. 1983 May-Jun;117(3-4):237-42. doi: 10.1016/0165-1218(83)90124-6.

DOI:10.1016/0165-1218(83)90124-6
PMID:6406881
Abstract

2 anti-chagasic drugs, nifurtimox and benznidazole, were assayed in the Salmonella/mammalian microsome test. These drugs were most active in strain TA100. Under certain experimental conditions, addition of rat-liver S9 mix led to a decrease in the number of his+ revertants induced by the drugs.

摘要

相似文献

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Mutagenicity of 2 anti-chagasic drugs and their metabolic deactivation.
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