Mutagenicity of 2 anti-chagasic drugs and their metabolic deactivation.
作者信息
Nagel R, Nepomnaschy I
出版信息
Mutat Res. 1983 May-Jun;117(3-4):237-42. doi: 10.1016/0165-1218(83)90124-6.
PMID:6406881
Abstract
2 anti-chagasic drugs, nifurtimox and benznidazole, were assayed in the Salmonella/mammalian microsome test. These drugs were most active in strain TA100. Under certain experimental conditions, addition of rat-liver S9 mix led to a decrease in the number of his+ revertants induced by the drugs.
摘要
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