Mechano-pharmacology of T cell receptor specificity.
作者信息
Fei Panyu, Dustin Michael L
机构信息
Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK.
出版信息
Cell Res. 2025 May;35(5):324-325. doi: 10.1038/s41422-025-01105-8.
Abstract
摘要
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本文引用的文献
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TCR catch bonds nonlinearly control CD8 cooperation to shape T cell specificity.TCR捕获键非线性地控制CD8协同作用以塑造T细胞特异性。
Cell Res. 2025 Apr;35(4):265-283. doi: 10.1038/s41422-025-01077-9. Epub 2025 Feb 27.
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Mechano-regulation of Peptide-MHC Class I Conformations Determines TCR Antigen Recognition.机械调节肽-MHC I 构象决定 TCR 抗原识别。
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A TCR mechanotransduction signaling loop induces negative selection in the thymus.T 细胞受体机械转导信号环路诱导胸腺中的负选择。
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Accumulation of dynamic catch bonds between TCR and agonist peptide-MHC triggers T cell signaling.TCR 与激动肽-MHC 之间动态结合键的积累触发 T 细胞信号转导。
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MHC-class I-restricted CD4 T cells: a nanomolar affinity TCR has improved anti-tumor efficacy in vivo compared to the micromolar wild-type TCR.MHC Ⅰ类限制性 CD4 T 细胞：与微摩尔野生型 TCR 相比，纳米摩尔亲和力 TCR 具有改善的体内抗肿瘤疗效。
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The kinetics of two-dimensional TCR and pMHC interactions determine T-cell responsiveness.二维 TCR 和 pMHC 相互作用的动力学决定了 T 细胞的反应性。
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TCR-peptide-MHC interactions in situ show accelerated kinetics and increased affinity.TCR-肽-MHC 相互作用的原位显示出加速的动力学和增加的亲和力。
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Engineering higher affinity T cell receptors using a T cell display system.利用T细胞展示系统构建高亲和力T细胞受体
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High-affinity TCRs generated by phage display provide CD4+ T cells with the ability to recognize and kill tumor cell lines.通过噬菌体展示产生的高亲和力T细胞受体赋予CD4+ T细胞识别和杀伤肿瘤细胞系的能力。
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In vitro evolution of a T cell receptor with high affinity for peptide/MHC.对肽/主要组织相容性复合体具有高亲和力的T细胞受体的体外进化
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