Yang Huitang, Zhang Tonghe, Li Zhaoyang, Cai Yandong, Jiang Zhan, Fan Guoju, Wang Kaiqiang, Chen Bo, Zhang Hongwei, Hu Hailong, Li Yankui
Department of Vascular Surgery, The Second Hospital of Tianjin Medical University, Tianjin, 300211, China.
Center for Cardiovascular Diseases, The Second Hospital of Tianjin Medical University, Tianjin, 300211, China.
BMC Cancer. 2025 Mar 24;25(1):536. doi: 10.1186/s12885-025-13939-x.
In this study, we retrospectively analyzed the incidence of and risk factors for in-hospital venous thromboembolism (VTE) in patients with bladder cancer and explored measures to reduce the incidence of and/or prevent in-hospital VTE and mortality.
The clinical data of 5744 patients with bladder cancer who were admitted to the Second Hospital of Tianjin Medical University during a 5-year period were summarized and then analyzed to determine the risk factors for in-hospital VTE in patients with bladder cancer with the aim of identifying preventive measures.
Univariate analysis revealed significant differences between the VTE group and the non-VTE group in terms of age, sex, Caprini score, surgical treatment status, tumor stage, D-dimer level, PT, APTT, and Hb (P < 0.05). Multiple factor analysis further confirmed that the Caprini score, surgical treatment status, D-dimer level, PT, and APTT were independent risk factors for VTE.
Analyses revealed that a high Caprini score, surgical treatment, an elevated D-dimer level, a short PT, and a short APTT were independent risk factors for in-hospital VTE in patients with bladder cancer and that active preventive measures should be implemented to reduce the incidence of in-hospital VTE as well as mortality.
本研究回顾性分析膀胱癌患者院内静脉血栓栓塞症（VTE）的发生率及危险因素，并探索降低院内VTE发生率和/或预防其发生及降低死亡率的措施。
总结天津医科大学第二医院5年内收治的5744例膀胱癌患者的临床资料，然后进行分析以确定膀胱癌患者院内VTE的危险因素，旨在确定预防措施。
单因素分析显示，VTE组与非VTE组在年龄、性别、Caprini评分、手术治疗情况、肿瘤分期、D-二聚体水平、PT、APTT和Hb方面存在显著差异（P < 0.05）。多因素分析进一步证实，Caprini评分、手术治疗情况、D-二聚体水平、PT和APTT是VTE的独立危险因素。
分析显示，高Caprini评分、手术治疗、D-二聚体水平升高、PT缩短和APTT缩短是膀胱癌患者院内VTE的独立危险因素，应采取积极的预防措施以降低院内VTE的发生率及死亡率。
