Zheng Hongqing, Qiu Cunyi, Tian Haolun, Zhu Xiaofu, Yin Baoying, Zhou Zhiding, Li Xuezhao, Zhao Jingjing
Xianyang Polytechnic Institute, Xianyang, 712000, China.
Gansu Polytechnic College of Animal Husbandry & Engineering, Wuwei, 733006, China.
Vet Res. 2025 Mar 24;56(1):67. doi: 10.1186/s13567-025-01500-4.
Porcine epidemic diarrhea is an acute contagious disease caused by porcine epidemic diarrhea virus (PEDV), which severely constrains the development of the global swine industry. Host restriction factors constitute a vital defensive barrier against viral infections, typically interacting with viruses at specific stages of their replication process to disrupt it. Considering that traditional PEDV vaccines often struggle to effectively activate mucosal immunity in sows and thereby fail to provide reliable passive immunity to piglets via milk, this review focuses on the host restriction factors that play crucial roles in restricting PEDV infection and replication. The aim is to identify potential targets for the development of anti-PEDV drugs and offer insights for the exploration of novel vaccine adjuvants.
猪流行性腹泻是由猪流行性腹泻病毒（PEDV）引起的一种急性传染病，严重制约着全球养猪业的发展。宿主限制因子构成了抵御病毒感染的重要防御屏障，通常在病毒复制过程的特定阶段与病毒相互作用以破坏其复制。鉴于传统的PEDV疫苗往往难以有效激活母猪的黏膜免疫，从而无法通过乳汁为仔猪提供可靠的被动免疫，本文综述聚焦于在限制PEDV感染和复制中起关键作用的宿主限制因子。目的是确定抗PEDV药物开发的潜在靶点，并为新型疫苗佐剂的探索提供思路。
