Longitudinal changes in peritoneal solute transport rate and the impact of lower glucose degradation product glucose dialysates.

INTRODUCTION

Peritoneal solute transfer rates (PSTR) are reported to increase with time. Changes in PSTR were reviewed in long-term peritoneal dialysis (PD) patients to determine whether lower glucose degradation products (low GDP) dialysates prevented an increase in PSTR.

METHODS

PSTR was determined with a 4-h peritoneal equilibrium test with a 2.0 L 22.7 g/L glucose dialysate.

RESULTS

One hundred twenty-three PD patients treated for ≥4 years, 47.2% male, age 61 ± 16 years, 31.7% diabetic. Initially, 15.6% were treated with low GDP dialysates, which rose to 44.7% at 6 years. Creatinine PSTR increased with standard glucose dialysates (0.72 ± 0.1 at Year 3 to 0.79 ± 0.1 Year 5 and 0.82 ± 0.1 Year 6, p < 0.05), whereas PSTR was stable and lower with low GDP dialysates (0.71 ± 0.1, 0.65 ± 0.1, 0.68 ± 0.1); p < 0.001 for Years 5 and 6.

CONCLUSION

Exposure to standard glucose dialysates resulted in faster peritoneal solute transfer rates over time, whereas peritoneal solute transfer rates appeared more stable with lower glucose degradation products dialysates.