Liu Jiayao, Li Na, Wang Bin, Zhao Wujie, Zhi Jie, Jia Xiaojing, Jia Yitao, Tie Yanqing
The Third Department of Oncology, Hebei General Hospital, Shijiazhuang, China.
Hebei Medical University, Shijiazhuang, China.
Cancer Med. 2025 Mar;14(6):e70795. doi: 10.1002/cam4.70795.
Cancer patients are particularly vulnerable to the psychological sequels of COVID-19 due to their immunocompromised state and the disruptions to their regular oncological care. There is limited research comparing the effects of SARS-CoV-2 on cancer patients and their co-living individuals. This study aims to explore the similarities and differences in physical and psychological outcomes between these two groups, with a 1-year follow-up to assess long-term effects.
This retrospective observational study was conducted between January and February 2023. A total of 107 participants were included: 72 cancer patients and 35 co-living individuals, all diagnosed with COVID-19. Clinical and laboratory data were collected. Depression, anxiety, and fatigue were assessed at two timepoints: shortly after COVID-19 diagnosis and 1 year later.
Cancer patients exhibited higher rates of gastrointestinal symptoms, such as diarrhea (20.83% vs. 5.71%, p = 0.045), which were associated with increased anxiety and depression (p < 0.05). Advanced-stage cancer (p < 0.01) and lack of vaccination (p < 0.01) correlated with worse psychological outcomes. Female cancer patients reported higher depression scores (p < 0.05). Laboratory findings indicated higher neutrophil percentages (p < 0.001), fibrinogen (p < 0.001), and D-dimer levels (p = 0.015) in cancer patients, signaling a higher risk of inflammation and thrombosis. Both groups showed improvements in depression and fatigue over the 1-year follow-up, but cancer patients continued to report greater psychological distress (p < 0.001) and fatigue (p = 0.024).
Cancer patients infected with COVID-19 experienced more severe physical and psychological symptoms compared to their co-living individuals, with persistent differences 1 year after infection.
ChiCTR2300067577.
癌症患者由于免疫功能低下以及常规肿瘤治疗受到干扰，特别容易受到新冠病毒病心理后遗症的影响。关于严重急性呼吸综合征冠状病毒2（SARS-CoV-2）对癌症患者及其共同生活的个体的影响的研究有限。本研究旨在探讨这两组人群在身体和心理结局方面的异同，并进行为期1年的随访以评估长期影响。
本回顾性观察性研究于2023年1月至2月进行。共纳入107名参与者：72名癌症患者和35名共同生活的个体，均被诊断为新冠病毒病。收集了临床和实验室数据。在两个时间点评估抑郁、焦虑和疲劳情况：新冠病毒病诊断后不久以及1年后。
癌症患者出现胃肠道症状的比例较高，如腹泻（20.83%对5.71%，p = 0.045），这与焦虑和抑郁增加有关（p < 0.05）。晚期癌症（p < 0.01）和未接种疫苗（p < 0.01）与更差的心理结局相关。女性癌症患者报告的抑郁评分较高（p < 0.05）。实验室检查结果表明，癌症患者的中性粒细胞百分比（p < 0.001）、纤维蛋白原（p < 0.001）和D-二聚体水平（p = 0.015）较高，表明炎症和血栓形成风险较高。在1年的随访中，两组的抑郁和疲劳情况均有改善，但癌症患者继续报告有更大的心理困扰（p < 0.001）和疲劳（p = 0.024）。
与共同生活的个体相比，感染新冠病毒病的癌症患者经历了更严重的身体和心理症状，感染1年后仍存在持续差异。
ChiCTR2300067577。
