Thoracic Medicine Department 1, Hunan Cancer Hospital/The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, China.
Department of Clinical Spiritual Care, Hunan Cancer Hospital/The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, China.
Psychooncology. 2022 Nov;31(11):1972-1987. doi: 10.1002/pon.6012. Epub 2022 Aug 19.
We aimed to assess the prevalence rate (PR) of depression, anxiety, posttraumatic stress disorder (PTSD), insomnia, distress, and fear of cancer progression/recurrence among patients with cancer during the COVID-19 pandemic.
Studies that reported the PR of six psychological disorders among cancer patients during the COVID-19 pandemic were searched in PubMed, Embase, PsycINFO, and Web of Science databases, from January 2020 up to 31 January 2022. Meta-analysis results were merged using PR and 95% confidence intervals, and heterogeneity among studies was evaluated using I and Cochran's Q test. Publication bias was examined using funnel plots and Egger's tests. All data analyses were performed using Stata14.0 software.
Forty studies with 27,590 participants were included. Pooled results showed that the PR of clinically significant depression, anxiety, PTSD, distress, insomnia, and fear of cancer progression/recurrence among cancer patients were 32.5%, 31.3%, 28.2%, 53.9%, 23.2%, and 67.4%, respectively. Subgroup analysis revealed that patients with head and neck cancer had the highest PR of clinically significant depression (74.6%) and anxiety (92.3%) symptoms. Stratified analysis revealed that patients with higher education levels had higher levels of clinically significant depression (37.2%). A higher level of clinically significant PTSD was observed in employed patients (47.4%) or female with cancer (27.9%).
This meta-analysis evaluated the psychological disorders of cancer patients during the COVID-19 outbreak. Therefore, it is necessary to develop psychological interventions to improve the mental health of cancer patients during the pandemic.
评估 COVID-19 大流行期间癌症患者中抑郁、焦虑、创伤后应激障碍（PTSD）、失眠、痛苦和对癌症进展/复发的恐惧的患病率（PR）。
在 PubMed、Embase、PsycINFO 和 Web of Science 数据库中检索了 COVID-19 大流行期间报告癌症患者六种心理障碍 PR 的研究，检索时间为 2020 年 1 月至 2022 年 1 月 31 日。使用 PR 和 95%置信区间合并荟萃分析结果，并使用 I 和 Cochran's Q 检验评估研究间的异质性。使用漏斗图和 Egger 检验检查发表偏倚。所有数据分析均使用 Stata14.0 软件进行。
共纳入 40 项研究，共 27590 名参与者。汇总结果显示，癌症患者中临床显著抑郁、焦虑、PTSD、痛苦、失眠和对癌症进展/复发的恐惧的 PR 分别为 32.5%、31.3%、28.2%、53.9%、23.2%和 67.4%。亚组分析显示，头颈部癌症患者的临床显著抑郁（74.6%）和焦虑（92.3%）症状患病率最高。分层分析显示，受教育程度较高的患者临床显著抑郁（37.2%）水平较高。在职患者（47.4%）或女性癌症患者（27.9%）的 PTSD 程度较高。
本荟萃分析评估了 COVID-19 大流行期间癌症患者的心理障碍。因此，有必要制定心理干预措施，以改善大流行期间癌症患者的心理健康。
