Yang Xinghuang, Liu Tianqi, Cheng Hong
Medical College, Yangzhou University, Yangzhou, China.
Jiangsu Key Laboratory of Experimental & Translational Non-Coding RNA Research, Yangzhou University Medical College, Institute of Translational Medicine, Yangzhou University, Yangzhou, China.
Front Cell Neurosci. 2025 Mar 10;19:1497555. doi: 10.3389/fncel.2025.1497555. eCollection 2025.
In recent years, the study of phosphatase and tension homolog (PTEN) has gradually become a research hotspot. As an important oncogene, the role of PTEN in cancer has long been widely recognized and intensively studied, but it has been relatively less studied in other diseases. Parkinson's disease (PD) is a neurodegenerative refractory disease commonly observed in middle-aged and elderly individuals. The etiology and pathogenesis of PD are numerous, complex, and incompletely understood. With the continuous deepening of research, numerous studies have proven that PTEN is related to the occurrence of PD. In this review, we discuss the relationship between PTEN and PD through the phosphorylation and ubiquitination of PTEN and other possible regulatory mechanisms, including the role of RNA molecules, exosomes, transcriptional regulation, chemical modification, and subtype variation, with the aim of clarifying the regulatory role of PTEN in PD and better elucidating its pathogenesis. Finally, we summarize the shortcomings of PTEN in PD research and highlight the great potential of its future application in PD clinical treatment. These findings provide research ideas and new perspectives for the possible use of PTEN as a PD therapeutic target for targeted drug development and clinical application in the future.
近年来，磷酸酶与张力蛋白同源物（PTEN）的研究逐渐成为一个研究热点。作为一种重要的抑癌基因，PTEN在癌症中的作用早已得到广泛认可并被深入研究，但在其他疾病中的研究相对较少。帕金森病（PD）是一种常见于中老年人的神经退行性难治性疾病。PD的病因和发病机制众多、复杂且尚未完全明确。随着研究的不断深入，大量研究已证明PTEN与PD的发生有关。在这篇综述中，我们通过PTEN的磷酸化和泛素化以及其他可能的调控机制，包括RNA分子、外泌体、转录调控、化学修饰和亚型变异的作用，来探讨PTEN与PD之间的关系，旨在阐明PTEN在PD中的调控作用并更好地阐明其发病机制。最后，我们总结了PTEN在PD研究中的不足之处，并强调了其未来在PD临床治疗中应用的巨大潜力。这些发现为未来可能将PTEN用作PD治疗靶点进行靶向药物开发和临床应用提供了研究思路和新的视角。
