Feng Weifeng, Liu Heqi
Department of Cosmetic Surgery, Beijing Badachu Plastic Surgery, Fifth Medical Aesthetic Hospital, Beijing, 102600, People's Republic of China.
Department of Anesthesiology, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, 100045, People's Republic of China.
Int Med Case Rep J. 2025 Mar 20;18:367-371. doi: 10.2147/IMCRJ.S510203. eCollection 2025.
Botulinum toxin serotype A (BTX-A) is commonly used for treating facial dynamic wrinkles. The clinical safety of BTX-A has been proven, and it has few side effects; despite this, BTX-A has the potential to cause an allergic reaction. This case raises concerns about a possible interaction between botulinum toxin serotype A (CBTX-A) and β-lactam antibiotics, contributing to the limited literature on hypersensitivity reactions. Herein, we described the case of a 35-year-old woman who was injected with Chinese botulinum toxin serotype A (CBTX-A) to treat crow's feet. The treatment was performed after the patient had taken cefprozil for an upper respiratory tract infection. Subsequently, the patient developed urticaria-like symptoms that completely resolved within 24 hours after administration of antihistamines. This case emphasises the need for careful medication history review before botulinum toxin administration, especially in patients receiving β-lactam antibiotics, as hypersensitivity reactions may occur.
A型肉毒杆菌毒素（BTX-A）常用于治疗面部动态皱纹。BTX-A的临床安全性已得到证实，且副作用较少；尽管如此，BTX-A仍有可能引起过敏反应。该病例引发了人们对A型肉毒杆菌毒素（CBTX-A）与β-内酰胺类抗生素之间可能存在相互作用的担忧，这也导致了关于过敏反应的文献有限。在此，我们描述了一名35岁女性的病例，她注射了中国产A型肉毒杆菌毒素（CBTX-A）以治疗鱼尾纹。该治疗是在患者因上呼吸道感染服用头孢丙烯之后进行的。随后，患者出现了荨麻疹样症状，在服用抗组胺药后24小时内完全消退。该病例强调了在注射肉毒杆菌毒素之前仔细审查用药史的必要性，尤其是在接受β-内酰胺类抗生素治疗的患者中，因为可能会发生过敏反应。
