Gel Mehmet Selim, Postuk Hasan Çağrı, Daltaban İskender Samet, Özer Savaş, Aydin Ercan, Keskin Emrah
Department of Neurosurgery Clinic, Trabzon Kanuni Training and Research Hospital, Trabzon, Turkiye.
Department of Neurosurgery Clinic, Ankara Alife Hospital, Ankara, Turkiye.
Turk J Med Sci. 2025 Jan 11;55(1):209-214. doi: 10.55730/1300-0144.5959. eCollection 2025.
BACKGROUND/AIM: A comprehensive risk factor assessment evaluating the susceptibility of cerebral aneurysms (CAs) to rupture has not yet been established. Therefore, the clinical management of unruptured CAs remains uncertain. This study aimed to assess whether arterial stiffness was associated with rupture risk in patients with CAs.
Following magnetic resonance angiography, 49 patients with CAs and subarachnoid haemorrhage and ruptured CAs (confirmed via digital subtraction angiography) were included in the study. Arterial stiffness was measured using the VaSera VS-1000 vascular scanning system and expressed as cardio-ankle vascular index (CAVI) values. The CAVI values were compared between the patient groups.
The mean age of the cerebrovascular aneurysm group was 51 ± 11 years, while that of the cerebrovascular aneurysmal haemorrhage group was 58 ± 12 (p = 0.308) years. Left and right CAVI values were significantly higher in the cerebrovascular aneurysm group (p < 0.05 for both). The CAVI values were positively correlated with haemorrhagic CA (p < 0.05).
This study revealed that increased arterial stiffness was associated with an increased risk of haemorrhage in patients with CAs. This result demonstrates the importance of evaluating arterial stiffness as an informative parameter for treatment and follow-up decisions in patients with CAs.
背景/目的：尚未建立一种全面的风险因素评估方法来评估脑动脉瘤（CA）破裂的易感性。因此，未破裂CA的临床管理仍不明确。本研究旨在评估动脉僵硬度是否与CA患者的破裂风险相关。
在进行磁共振血管造影后，本研究纳入了49例患有CA且发生蛛网膜下腔出血以及破裂CA（经数字减影血管造影证实）的患者。使用VaSera VS - 1000血管扫描系统测量动脉僵硬度，并以心踝血管指数（CAVI）值表示。比较了各患者组之间的CAVI值。
脑血管动脉瘤组的平均年龄为51±11岁，而脑血管动脉瘤性出血组的平均年龄为58±12岁（p = 0.308）。脑血管动脉瘤组的左右CAVI值均显著更高（两者p均<0.05）。CAVI值与出血性CA呈正相关（p < 0.05）。
本研究表明，动脉僵硬度增加与CA患者出血风险增加相关。这一结果证明了将动脉僵硬度作为CA患者治疗和随访决策的一个信息性参数进行评估的重要性。
