Song Siyu, Sun Xirao, Wang Yanfu, Wang Meng, Shi Zheng, Sun Danfang, Li Dan, Chen Jianduo, Wang Chengyue
Jinzhou Medical University School of Stomatology, Jinzhou, China.
Stomatology Hospital Affiliated of Jinzhou Medical University, Jinzhou, China.
Front Pharmacol. 2025 Mar 10;16:1543678. doi: 10.3389/fphar.2025.1543678. eCollection 2025.
Oral squamous cell carcinoma (OSCC) usually invades the jawbone over the course of the disease. Hence, it is necessary to consider the treatment of the tumor and repair of the jawbone, and the treatment process is very complicated. However, conventional therapy for OSCC mainly emphasizes tumor removal, which often fails to address the repair of jawbone defects and destroys residual tumor cells after treatment.
In this study, we designed a composite hydrogel platform (SUMg) of sodium alginate loaded upconversion nanoparticles (UCNP) and magnesium particles (MPs), in which UCNP was coated with folic acid and chlorin e6 to prepare UFC. The physicochemical and biological properties of the prepared SUMg, including swelling test, element mapping, cell behaviors, osteogenic bioactivity and antitumor effect, were comprehensively evaluated.
, SUMg exhibited high cytocompatibility and promoted cell viability, proliferation, spreading, and osteogenesis owing to the incorporation of MPs, with SU10 Mg having the most significant effect. Under 980 nm laser irradiation, UFC induced a photodynamic therapy effect and destroyed surviving tumor cells. experiments further confirmed that SU10 Mg could promote bone regeneration, and under 980 nm near-infrared irradiation, the UFC produced local reactive oxygen species in the tumor within 5 min.
This work demonstrated the potential of SUMg in bone regeneration and inhibition of tumor growth, providing valuable insight for OSCC treatment.
口腔鳞状细胞癌（OSCC）在疾病发展过程中通常会侵犯颌骨。因此，有必要考虑肿瘤的治疗和颌骨修复，且治疗过程非常复杂。然而，OSCC的传统治疗主要侧重于肿瘤切除，往往无法解决颌骨缺损的修复问题，并且会破坏治疗后残留的肿瘤细胞。
在本研究中，我们设计了一种负载上转换纳米颗粒（UCNP）和镁颗粒（MPs）的海藻酸钠复合水凝胶平台（SUMg），其中UCNP用叶酸和氯e6包覆制备成UFC。对制备的SUMg的物理化学和生物学性质，包括溶胀试验、元素映射、细胞行为、成骨生物活性和抗肿瘤作用进行了全面评估。
SUMg表现出高细胞相容性，并由于MPs的掺入促进了细胞活力、增殖、铺展和成骨，其中SU10 Mg的效果最为显著。在980nm激光照射下，UFC诱导光动力治疗效果并破坏存活的肿瘤细胞。实验进一步证实SU10 Mg可促进骨再生，在980nm近红外照射下，UFC在5分钟内在肿瘤内产生局部活性氧。
这项工作证明了SUMg在骨再生和抑制肿瘤生长方面的潜力，为OSCC治疗提供了有价值的见解。
