Park Su Jeong, Lim Ho-Kyung, Lee Sung-Jae, Im Seung Hyuk, Lee Jong Min, Jung Youngmee, Kim Soo Hyun, Shim Ji-Seok, Won Jong-Eun, Chung Justin J, Song In-Seok
NBIT, KU-KIST Graduate School of Converging Science and Technology, Korea University, Seoul 02841, Republic of Korea.
Center for Biomaterials, Biomedical Research Institute, Korea Institute of Science and Technology, Seoul 02792, Republic of Korea.
Biomacromolecules. 2025 Apr 14;26(4):2390-2401. doi: 10.1021/acs.biomac.4c01768. Epub 2025 Mar 25.
The use of biodegradable materials in bone plates offers remarkable advantages; however, their application in bone fixation is limited by their brittleness. Moreover, treatments tailored to patient conditions are needed in orthopedics. In this study, bone plates were fabricated with stereocomplex polylactic acid (scPLA) and the effects of poly(d-lactic acid) molecular weight and scPLA blending ratios were analyzed. Although modulus values of poly(l-lactic acid) (PLLA) and scPLA were similar, strain resistance improved at higher scPLA proportions. The enhanced elongation was owing to the presence of tie molecules within the scPLA as opposed to single PLA chains. The fabricated scPLA bone plates exhibited improved mechanical properties and transparency in the optical and near-infrared ranges. scPLA was characterized by a smaller crystallite size. These properties of scPLA combined with its biocompatibility indicate potential for various diagnostic and therapeutic orthopedic applications. Comparisons with commercial PLLA-based bone plates show no significant differences in in vivo bone-healing ability.
在骨板中使用可生物降解材料具有显著优势；然而，它们在骨固定中的应用受到其脆性的限制。此外，骨科需要针对患者病情进行定制治疗。在本研究中，用立体复合聚乳酸（scPLA）制备了骨板，并分析了聚（d-乳酸）分子量和scPLA混合比例的影响。尽管聚（l-乳酸）（PLLA）和scPLA的模量值相似，但在较高的scPLA比例下，抗应变能力有所提高。伸长率的提高归因于scPLA中存在连接分子，而不是单一的PLA链。制备的scPLA骨板在光学和近红外范围内表现出改善的机械性能和透明度。scPLA的特征是微晶尺寸较小。scPLA的这些特性及其生物相容性表明其在各种骨科诊断和治疗应用中具有潜力。与基于商业PLLA的骨板相比，体内骨愈合能力没有显著差异。
