Wächter Sabine, Bartsch Detlef K
Klinik Klinik für Visceral‑, Thorax- und Gefäßchirurgie, Philipps-Universität Marburg, Baldingerstraße, 35043, Marburg, Deutschland.
Chirurgie (Heidelb). 2025 Mar 25. doi: 10.1007/s00104-025-02277-0.
Anaplastic thyroid cancer (ATC) is the rarest but also the most aggressive carcinoma entity of the thyroid gland. In recent years, treatment options have evolved and molecular oncological treatment approaches have gained in importance. The neoadjuvant use of these innovative therapies has the potential to convert previously unresectable tumors into a resectable state, thereby expanding surgical options and significantly improving the prognosis of patients. This article provides recommendations relevant for surgery for the diagnostics and treatment of ATC, based on a current literature review and the discussions of the S3 guideline conferences.
间变性甲状腺癌（ATC）是甲状腺最罕见但也是侵袭性最强的癌种。近年来，治疗方案不断发展，分子肿瘤学治疗方法愈发重要。这些创新疗法的新辅助应用有可能将先前无法切除的肿瘤转化为可切除状态，从而扩大手术选择范围并显著改善患者预后。本文基于当前文献综述以及S3指南会议的讨论结果，提供与ATC诊断和治疗手术相关的建议。
