Yan Qiang, Nan Jiang, Zhu Lanxin, Cao Rui, Liu Shilei
College of Chemistry and Chemical Engineering, Shaanxi University of Science and Technology, Xi'an 710021, China.
Xi'an Key Laboratory of Antiviral and Antimicrobial-Resistant Bacteria Therapeutics Research, Xi'an 710021, China.
Org Lett. 2025 Apr 4;27(13):3308-3313. doi: 10.1021/acs.orglett.5c00677. Epub 2025 Mar 25.
A new catalytic conversion type of nitro substrate with CO as a single-carbon source is presented, wherein a great collection of azaheterocycles is generated by a newly established iridium-catalyzed, copper-induced reductive system. This catalytic procedure handily employs poly(methylhydrosiloxane) (PMHS) as the reductant to simultaneously realize the dual reduction of the highest oxidation-state nitro and CO units in one operation. Elaborate mechanistic studies illustrate the essential role of the iridium catalyst in reducing the NO moiety as well as the double functions of the copper additive in the subsequent formylation and C-H cyclization steps.
