The mechanisms of human tumour-induced osteolysis and hypercalcaemia.

This is a brief resume of the current knowledge regarding the mechanisms whereby tumours may cause the breakdown or increase the turnover of bone matrix resulting in hypercalcaemia. The precise mechanisms and agents still remain to be ascertained. This would appear to be an investigative area worthy of significant research effort in view of the potential benefit to patient care which may then ensue.