术前东部肿瘤协作组（ECOG）体能状态作为上尿路尿路上皮癌手术预后的预测指标。
Preoperative ECOG performance status as a predictor of outcomes in upper tract urothelial cancer surgery.
作者信息
Yang Tsung-Mu, Chen I-Hsuan Alan, Yu Chia-Cheng, Yang Chi-Rei, Chen Wen-Chi, Lin Po-Hung, Pang See-Tong, Huang Steven Kuan-Hua, Chen Zhi-Hao, Tseng Jen-Shu, Lin Wun-Rong, Tsai Yao-Chou, Yu Chih-Chin, Chen Pi-Che, Cheong Ian-Seng, Jiang Yuan-Hong, Wu Chia-Chang, Huang Hsu-Che, Tai Ting-En, Tsai Chung-You, Lin Wei-Yu, Chen Yung-Tai, Wu Richard Chen-Yu, Lee Hsiang-Ying, Yeh Hsin-Chih
机构信息
Department of Urology, Kaohsiung Medical University Hospital, No. 100, Tzyou 1st Rd., Sanmin District, Kaohsiung, 807377, Taiwan.
Division of Urology, Department of Surgery, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan.
出版信息
Sci Rep. 2025 Mar 26;15(1):10356. doi: 10.1038/s41598-025-95128-1.
Eastern Cooperative Oncology Group performance status (ECOG-PS) is a widely used functional status measure in oncology, yet its prognostic value in upper tract urothelial carcinoma remains unclear. In this multicenter study of 2473 patients undergoing radical nephroureterectomy, ECOG-PS ≥ 2 was independently associated with worse overall survival (hazard ratio [HR] 2.53, p < 0.001), cancer-specific survival (HR 2.02, p < 0.001), and disease-free survival (HR 1.50, p = 0.003) than those with ECOG-PS 0-1. They also had a higher risk of major perioperative complications (odds ratio 2.46, p < 0.001). These findings support ECOG-PS as a valuable preoperative risk stratification tool.
东部肿瘤协作组体能状态（ECOG-PS）是肿瘤学中广泛使用的功能状态衡量指标，但其在上尿路尿路上皮癌中的预后价值仍不明确。在这项对2473例接受根治性肾输尿管切除术患者的多中心研究中，与ECOG-PS为0-1的患者相比，ECOG-PS≥2与较差的总生存期（风险比[HR] 2.53，p<0.001）、癌症特异性生存期（HR 2.02，p<0.001）和无病生存期（HR 1.50，p = 0.003）独立相关。他们发生围手术期重大并发症的风险也更高（比值比2.46，p<0.001）。这些发现支持将ECOG-PS作为一种有价值的术前风险分层工具。
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