Yang Ruonan, Lv Mingyue, Yang Xiujuan, Zhai Siwei
Department of Medical Quality Control, Chengdu Seventh People's Hospital, Chengdu, Sichuan, China.
The Sixth Affiliated Hospital of Shenzhen University, Shenzhen, Guangdong, China.
Sci Rep. 2025 Mar 25;15(1):10341. doi: 10.1038/s41598-025-94369-4.
Cardiovascular diseases (CVD) are a major global mortality cause, heavily impacted by diet and oxidative stress. This study investigates the causal effects of five circulatory antioxidants on various cardiovascular diseases using Mendelian randomization (MR) to mitigate confounding biases.We conducted a two-sample Mendelian Randomization (MR) analysis utilizing summary-level genome-wide association study (GWAS) data from both the UK Biobank and FinnGen. Genetic instrumental variables for antioxidants, including vitamin A, beta-carotene, vitamin C, α-tocopherol, and lycopene, were identified based on rigorous criteria. The outcomes included arrhythmia, cardiomyopathy, heart failure, myocardial infarction, pericarditis, angina pectoris and coronary atherosclerosis.Higher genetically determined levels of α-tocopherol were associated with an increased risk of myocardial infarction (OR 5.10, 95% CI 2.92-8.91, P < 0.001) and cardiac arrhythmias (OR 1.94, 95% CI 1.34-2.83, P = 0.001). Retinol was linked to heightened risks of cardiomyopathy (OR 6.38, 95% CI 1.23-33.20, P = 0.028) and heart failure (OR 2.26, 95% CI 1.01-5.07, P = 0.047). A meta-analysis corroborated the pathogenic effects of α-carotene on arrhythmias (OR, 2.00; 95% CI, 1.39-2.86; P < 0.001) and myocardial infarction (OR, 4.81; 95% CI, 2.84-8.15; P < 0.001), α-tocopherol on angina pectoris (OR: 4.33; 95% CI: 2.07-9.09; P < 0.001) and coronary atherosclerosis (OR: 5.34; 95% CI: 2.81-10.12; P < 0.001).Our study indicates that elevated levels of specific antioxidants, particularly α-tocopherol and retinol, may increase the risk of certain cardiovascular diseases. Further research is necessary to clarify the impact of these antioxidants on cardiovascular health and to explore potential gene-environment interactions.
心血管疾病（CVD）是全球主要的死亡原因，饮食和氧化应激对其影响很大。本研究使用孟德尔随机化（MR）来减轻混杂偏倚，调查了五种循环抗氧化剂对各种心血管疾病的因果效应。我们利用来自英国生物银行和芬兰基因库的汇总水平全基因组关联研究（GWAS）数据进行了两样本孟德尔随机化（MR）分析。根据严格标准确定了抗氧化剂的基因工具变量，包括维生素A、β-胡萝卜素、维生素C、α-生育酚和番茄红素。研究结果包括心律失常、心肌病、心力衰竭、心肌梗死、心包炎、心绞痛和冠状动脉粥样硬化。较高的基因决定的α-生育酚水平与心肌梗死风险增加（比值比5.10，95%置信区间2.92-8.91，P<0.001）和心律失常（比值比1.94，95%置信区间1.34-2.83，P=0.001）相关。视黄醇与心肌病风险增加（比值比6.38，95%置信区间1.23-33.20，P=0.028）和心力衰竭（比值比2.26，95%置信区间1.01-5.07，P=0.047）有关。一项荟萃分析证实了α-胡萝卜素对心律失常（比值比2.00；95%置信区间1.39-2.86；P<0.001）和心肌梗死（比值比4.81；95%置信区间2.84-8.15；P<0.001）、α-生育酚对心绞痛（比值比4.33；95%置信区间2.07-9.09；P<0.001）和冠状动脉粥样硬化（比值比5.34；95%置信区间2.81-10.12；P<0.001）的致病作用。我们的研究表明，特定抗氧化剂水平升高，尤其是α-生育酚和视黄醇，可能会增加某些心血管疾病的风险。有必要进一步研究以阐明这些抗氧化剂对心血管健康的影响，并探索潜在的基因-环境相互作用。
