Department of Glaucoma, National Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China.
Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou, China.
Transl Vis Sci Technol. 2024 Feb 1;13(2):20. doi: 10.1167/tvst.13.2.20.
This study aimed to investigate the genetic causal relationships among diet-derived circulating antioxidants, primary open-angle glaucoma (POAG), and glaucoma-related traits using two-sample Mendelian randomization (MR).
Genetic variants associated with diet-derived circulating antioxidants (retinol, ascorbate, β-carotene, lycopene, α-tocopherol, and γ-tocopherol) were assessed as absolute and metabolic instrumental variables. POAG and glaucoma-related traits data were derived from a large, recently published genome-wide association study database; these traits included intraocular pressure (IOP), macular retinal nerve fiber layer (mRNFL) thickness, macular ganglion cell-inner plexiform layer (mGCIPL) thickness, and vertical cup-to-disc ratio (vCDR). MR analyses were performed per outcome for each exposure.
We found no causal association between six diet-derived antioxidants and POAG using the International Glaucoma Genetics Consortium data. For absolute antioxidants, the odds ratios (ORs) ranged from 1.011 (95% confidence interval [CI], 0.854-1.199; P = 0.895) per natural log-transformed β-carotene to 1.052 (95% CI, 0.911-1.215; P = 0.490) for 1 µmol/L of ascorbate. For antioxidant metabolites, the OR ranged from 0.998 (95% CI, 0.801-1.244; P = 0.989) for ascorbate to 1.210 (95% CI, 0.870-1.682; P = 0.257) for γ-tocopherol, using log-transformed levels. A similar result was obtained with the FinnGen Biobank. Furthermore, our results showed no significant genetic association between six diet-derived antioxidants and glaucoma-related traits.
Our study did not support a causal association among six diet-derived circulating antioxidants, POAG, and glaucoma-related traits. This suggests that the intake of antioxidants may not have a preventive effect on POAG and offers no protection to retinal nerve cells.
This study provides valid evidence regarding the use of diet-derived antioxidants for glaucoma patients.
本研究旨在通过两样本 Mendelian 随机化（MR）方法，研究饮食源性循环抗氧化剂、原发性开角型青光眼（POAG）和青光眼相关特征之间的遗传因果关系。
评估与饮食源性循环抗氧化剂（视黄醇、抗坏血酸、β-胡萝卜素、番茄红素、α-生育酚和γ-生育酚）相关的遗传变异作为绝对和代谢工具变量。POAG 和青光眼相关特征数据来自最近发表的大型全基因组关联研究数据库；这些特征包括眼内压（IOP）、黄斑视网膜神经纤维层（mRNFL）厚度、黄斑神经节细胞-内丛状层（mGCIPL）厚度和垂直杯盘比（vCDR）。对每种暴露因素的每种结果进行 MR 分析。
我们发现，使用国际青光眼遗传学联合会的数据，六种饮食源性抗氧化剂与 POAG 之间没有因果关系。对于绝对抗氧化剂，每个自然对数转化的β-胡萝卜素的比值比（OR）范围为 1.011（95%置信区间 [CI]，0.854-1.199；P=0.895），而每个 1μmol/L 的抗坏血酸的 OR 为 1.052（95%CI，0.911-1.215；P=0.490）。对于抗氧化剂代谢物，OR 范围从抗坏血酸的 0.998（95%CI，0.801-1.244；P=0.989）到γ-生育酚的 1.210（95%CI，0.870-1.682；P=0.257），使用对数转换水平。在 FinnGen 生物库中也得到了类似的结果。此外，我们的结果表明，六种饮食源性抗氧化剂与青光眼相关特征之间没有显著的遗传关联。
我们的研究结果不支持六种饮食源性循环抗氧化剂、POAG 和青光眼相关特征之间存在因果关系。这表明，抗氧化剂的摄入可能对 POAG 没有预防作用，也不能保护视网膜神经细胞。
翻译结果仅供参考，你可以根据实际需求进行调整。
