Eldemir Kader, Ozkul Cagla, Yildirim Muhammed Seref, Eldemir Sefa, Saygili Fettah, Irkec Ceyla, Guclu-Gunduz Arzu
Department of Physiotherapy and Rehabilitation, Faculty of Health Sciences, Sivas Cumhuriyet University, Sivas, Turkey.
Department of Physiotherapy and Rehabilitation, Faculty of Health Sciences, Gazi University, Bişkek Caddesi, 6. Sokak, No:2 Çankaya, 06490, Ankara, Turkey.
Acta Neurol Belg. 2025 Jun;125(3):801-810. doi: 10.1007/s13760-025-02768-1. Epub 2025 Mar 26.
Multiple sclerosis (MS) is a chronic autoimmune disease causing sensory and motor impairments due to central nervous system demyelination. Sensory feedback, essential for balance and gait, is often disrupted in people with MS (PwMS). However, its relationship with fatigue, physical activity, cognitive function, and body awareness remains unclear.
To investigate the relationship between plantar sensation, knee position sense, and clinical factors in PwMS compared to healthy controls (HC).
Thirty-three PwMS and 11 HC participated in this study. Foot sensations including light touch threshold, two-point discrimination, vibration duration, and knee position sense were assessed. In addition, physical activity level, cognitive function, body awareness, and fatigue were assessed as clinical factors.
No significant differences were found between PwMS and HC in most sensory measures, except for body awareness, which was higher in HC (p:0.029). In PwMS, light touch thresholds correlated with age (r = 0.454, p = 0.008), vibration duration with walking and physical activity levels (r = 0.392-0.396, p < 0.05), two-point discrimination with EDSS score (r = 0.474, p = 0.005), knee position sense with EDSS (r = 0.385, p = 0.027) and cognitive function (r = 0.382, p = 0.028). In HC, vibration duration correlated negatively with age (r=-0.834, p:0.001), and knee position sense correlated with body mass index (r = 0.764, p:0.006) and cognitive function (r = 0.609-0.736, p < 0.05).
These findings highlight the relationship between sensory function and clinical factors in PwMS, emphasizing the importance of age, disability level, physical activity, and cognitive function in preserving the sensory functions of the lower extremity.
NCT04548297.
多发性硬化症（MS）是一种慢性自身免疫性疾病，由于中枢神经系统脱髓鞘导致感觉和运动障碍。感觉反馈对于平衡和步态至关重要，在多发性硬化症患者（PwMS）中常常受到干扰。然而，其与疲劳、身体活动、认知功能和身体意识之间的关系仍不清楚。
与健康对照（HC）相比，研究PwMS患者的足底感觉、膝关节位置觉与临床因素之间的关系。
33例PwMS患者和11例HC参与了本研究。评估了包括轻触觉阈值、两点辨别觉、振动持续时间和膝关节位置觉在内的足部感觉。此外，还评估了身体活动水平、认知功能、身体意识和疲劳等临床因素。
在大多数感觉测量中，PwMS患者和HC之间未发现显著差异，但身体意识除外，HC的身体意识更高（p：0.029）。在PwMS患者中，轻触觉阈值与年龄相关（r = 0.454，p = 0.008），振动持续时间与步行和身体活动水平相关（r = 0.392 - 0.396，p < 0.05），两点辨别觉与扩展残疾状态量表（EDSS）评分相关（r = 0.474，p = 0.005），膝关节位置觉与EDSS相关（r = 0.385，p = 0.027）以及认知功能相关（r = 0.382，p = 0.028）。在HC中，振动持续时间与年龄呈负相关（r = -0.834，p：0.001），膝关节位置觉与体重指数相关（r =
