Chokwassanasakulkit Trairong, McMillan Nigel A J
Institute of Biomedicine and Glycomics and School and Pharmacy and Medical Sciences, Griffith University, Gold Coast, Australia.
Exp Dermatol. 2025 Mar;34(3):e70092. doi: 10.1111/exd.70092.
This meta-analysis presents findings from nine studies involving 4626 cases of primary Merkel cell carcinoma (MCC), aimed at evaluating the relationship between primary MCC and the incidence of a second skin cancer. The analysis reveals a significant association, with a calculated risk ratio of 2.97 (95% CI, 1.70-5.19, p = 0.0001), indicating that individuals diagnosed with primary MCC are nearly three times more likely to develop the second skin cancer compared to patients with other second cancers. Among the second skin cancers analysed, basal cell carcinoma (BCC) showed the highest risk (0.69, 95% CI 0.35-1.37), followed by squamous cell carcinoma (SCC) (0.45, 95% CI 0.23-0.90) and melanoma (0.31, 95% CI 0.19-0.50). While geographic analysis showed that patients in Northern Europe have a non-significant 1.7-fold increased likelihood of developing the second skin cancer relative to those in North America (USA), where the likelihood of developing the second skin cancer is significantly lower at 0.7 times. The results underscore the importance of implementing enhanced surveillance and preventive strategies for individuals at increased risk. By identifying these associations, we may improve the early detection of the second skin cancer in patients with MCC.
这项荟萃分析展示了来自9项研究的结果，这些研究涉及4626例原发性默克尔细胞癌（MCC）病例，旨在评估原发性MCC与第二种皮肤癌发病率之间的关系。分析显示存在显著关联，计算得出的风险比为2.97（95%置信区间，1.70 - 5.19，p = 0.0001），这表明被诊断为原发性MCC的个体发生第二种皮肤癌的可能性几乎是患有其他第二种癌症患者的三倍。在分析的第二种皮肤癌中，基底细胞癌（BCC）风险最高（0.69，95%置信区间0.35 - 1.37），其次是鳞状细胞癌（SCC）（0.45，95%置信区间0.23 - 0.90）和黑色素瘤（0.31，95%置信区间0.19 - 0.50）。地域分析表明，相对于北美（美国）患者，北欧患者发生第二种皮肤癌的可能性增加了1.7倍，但差异不显著，而北美患者发生第二种皮肤癌的可能性显著较低，为0.7倍。结果强调了对风险增加的个体实施强化监测和预防策略的重要性。通过识别这些关联，我们或许可以改善MCC患者第二种皮肤癌的早期检测。
